Retina

Providing patients with renewed hope and the chance of halting and maybe even reversing vision loss, the launch of this anti-VEGF therapy has signalled a permanent change in the way this debilitating disorder is treated worldwide.

New treatments have not only caused major shifts in practice patterns but have also presented feasible options for pathologies other than those for which they were initially developed.

Second Sight's "bionic eye" implant, the Argus II Retinal Prosthesis System, has been implanted into two blind patients at London's Moorfields Eye Hospital by Dr Lyndon da Cruz and team.

Spectral domain, three-dimensional (3-D), high-resolution optical coherence tomography (OCT) represents a step forward in OCT technology, with precise registration, complete data set acquisition, and improved coverage of the retina being the major advantages.

VEGFb, a novel form of vascular endothelial growth factor (VEGF), an anti-angiogenic which is cytoprotective for retinal cells, can inhibit choroidal neovascularization significantly, according to preclinical results presented at this year's BIO National Venture Conference, held April 22?23 in Cambridge, US.

Cortiject, Novagali Pharma's investigational treatment for Diabetic Macular Oedema (DME), has successfully been injected into the first patient in its Phase I clinical trial.

Patients with retinal dystrophy experience slower disease progression when treated with the α2 agonist brimonidine, according to a study published in the February 2008 issue of the Journal of Ocular Pharmacology and Therapeutics.

The FDA has approved an expansion of the Phase III CABERNET (CNV Secondary to AMD Treated with BEta RadiatioN Epiretinal Therapy) trial, which is evaluating the safety and efficacy of NeoVista's epiretinal brachytherapy in wet age-related macular degeneration (AMD).

The P200C, a retinal imaging device designed for advanced ocular disease, has been launched by Optos plc.

Regeneration of damaged retinal cells with the aid of stem cells may offer hope for the treatment of retinal degeneration conditions, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR), according to a report published by the National Academy of Sciences (Volume 103).

Vitreoretinal Technologies, Inc has begun to enrol and treat diabetic retinopathy patients in the clinical trial for its pharmaceutical treatment Vitreosolve.

Intravitreal medical therapy for age-related macular degeneration (AMD) is dominated by the two anti-vascular endothelial growth factor (VEGF) drugs, ranibizumab and bevacizumab (Lucentis and Avastin, respectively, Genentech).

Age-related macular degeneration (AMD) may be a useful indicator for predicting death from stroke or cardiovascular disease, according to a study published online ahead of print by the British Journal of Ophthalmology.

NeoVista Inc?s epiretinal brachytherapy for wet AMD in combination with Avastin (bevacizumab) has been shown to improve mean visual acuity (VA) in patients, with adverse events restricted to vitrectomy-related problems and not to radiation toxicity, according to results of a Phase II trial presented at the 31st Annual Macula Society Meeting in Palm Beach, Florida, US.

Lucentis (ranibizumab; Novartis) is to be made available to all patients of the National Health Service (NHS) in England and Wales, according to a report from the BBC. The final appraisal document (FAD) has been published ahead of final guidance, expected in June 2008.

A low rate of endophthalmitis can be achieved after intravitreal triamcinolone injection without the use of antibiotic prophylaxis on the pretreatment days, said Abdhish R. Bhavsar, MD, at the annual meeting of the American Society of Retina Specialists.

Injection-related complications such as infectious endophthalmitis, retinal detachment, and traumatic cataract may occur with a frequency of about 0.15% after intravitreal injections of bevacizumab or triamcinolone, independently of the drug injected, according to a study published in the February issue of Eye.

Visudyne (verteporfin) and Avastin (bevacizumab) combination therapy reduces the number of retreatments needed by half, according to Phase II study results presented at the annual Macula Society Conference in Florida, US.

Bevacizumab can produce remarkable results in infants with severe retinopathy of prematurity (ROP), according to a free paper presented at the All India Ophthalmological Society meeting held in Bangalore earlier this year.

Shortening of retinal laser exposure time is just as effective as conventional, longer laser exposure in patients undergoing laser photocoagulation, but is significantly less painful, according to a study published in the January issue of Eye.

Patients who are currently hospitalized overnight for vitreoretinal surgery could safely be treated as day cases, thus providing significant improvements in efficiency, according to a report published in the February issue of Eye.

The cumulative experience of more than 20 years of treating retinal diseases with a variety of lasers has taught clinicians and researchers one very important lesson: less is more.

A protein, called Robo4, has been identified which appears to play an important role in the development of stable, working blood vessels.

The incidence of endophthalmitis following injections of anti-VEGF drugs is lower when the injections are given in an office setting than the rates reported from clinical trials, which require a more extensive pre-injection regimen.

According to a presentation at the All India Ophthalmological Society meeting, when used appropriately, bevacizumab can produce remarkable results in children with severe retinopathy of prematurity (ROP).