Presbyopia

The formulation combines 2 pharmacologic agents: carbachol, a direct-acting cholinergic agonist, and brimonidine tartrate, an alpha-2 adrenergic receptor agonist.

The FDA has assigned a PDUFA goal date of October 17, 2026.

Cataract surgeons discuss their comprehensive approach to IOL counseling

Tenpoint Therapeutics’ YUVEZZI, expected in the US in Q2 2026, is the first fixed-dose combination drop designed to improve near vision via pupil modulation with once-daily dosing.

A study reveals that low-dose pilocarpine effectively reduces pupil size in presbyopic eyes with minimal impact on lens thickness and accommodation.

Formerly, the EDOF technology was specifically limited to intraocular lenses.

This is the first submission for approval under the exclusive license and commercialization agreement for South Korea that was signed between LENZ and Lotus.

The topical ophthalmic solution is preservative-free and includes dual lubricants—hyaluronic acid and hydroxypropyl methylcellulose—for patient comfort.

How pupil modulation and pharmacologic targeting shape near vision outcomes.

Vizz is the first and only FDA-approved aceclidine-based eye drop for the treatment of presbyopia in adults

Innovation, adaptability, and clear communication are key to managing outcomes.

Advances address a need for the growing populace with age-related near vision loss.

Vizz (Lenz Therapeutics) is the first and only aceclidine-based eye drop for presbyopia and is also the first daily solution to correct vision for up to 10 hours.

LENZ Therapeutics previously licensed Greater China rights to CORXEL for the development and commercialization of LNZ100 in April 2022.

Phentolamine Ophthalmic Solution 0.75% is a non-selective alpha-1 and alpha-2 adrenergic antagonist to reduce pupil size, administered as an eye drop for the treatment of presbyopia.

The FDA has set a Prescription Drug User Fee Act (PDUFA) date of January 28, 2026.

Alex Hacopian, MD, highlights how a recent ambispective study demonstrated strong visual acuity outcomes and patient satisfaction following bilateral implantation of an advanced presbyopia-correcting intraocular lens.

Updated guidelines characterize IOLs by functional performance over optical design.

Personalizing treatment options and setting realistic expectations are crucial.

BRIMOCHOL PF’s combination of brimonidine and carbachol produces a “pinhole effect,” which is intended to improve depth of focus and sharpen near and distant impact.

The novel corrective eye drop can be prescribed through pharmacy partners BlinkRx or Medvantx

Patients’ near visual needs is important when prescribing medications for glaucoma treatment

The clinical trial successfully met pre-specified visual acuity primary endpoints in both the US and European Union (EU)/United Kingdom (UK) with statistically significant near vision improvements recorded at all time points over 8 hours