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All 696 patients in the trial have completed their treatment and follow-up visits. 

Nicox completes phase 3 Denali trial of NCX 470 in open-angle glaucoma or ocular hypertension

Patients express mixed feelings about AI in healthcare, favoring its use for documentation and administrative tasks while demanding transparency and safety standards.

Most patients support AI in healthcare if it means more time with doctors

The VAC will be a strategic team informing Nanoscope’s scientific, clinical, and community-facing efforts.

Nanoscope Therapeutics forms Vision Advisory Committee 

Sanaregen Vision Therapeutics invites investors to reserve shares as it prepares for an equity crowdfunding campaign to advance retinal disease treatments.

Sanaregen Vision Therapeutics invites prospective investors to reserve stock shares

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Ophthalmology Times – Clinical Insights for Eye Specialists

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Clinical

Glaucoma

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Sahar Bedrood, MD, PhD, glaucoma and cataract specialist at Acuity Eye Group (Pasadena, CA), clinical assistant professor at USC Roski Eye Institute, shares her clinical perspective on the evolution of interventional glaucoma, including the shift in standard treatment procedures and why taking an active approach to treating patients is key for success.

In this latest EyePod® episode, Sahar Bedrood, MD, PhD, shares her clinical perspective on the multi-faceted, dynamic evolution of interventional glaucoma. 

Exploring the evolution of interventional glaucoma



During AAO 2020, Thomas Samuelson, MD, speaks on the outcomes of a three-year trial analyzing the iStent inject trabecular micro-bypass + phaco versus phaco alone in patients with POAG.

Thomas Samuelson, MD, speaks on the outcomes of a three-year trial analyzing the iStent inject trabecular micro-bypass + phaco versus phaco alone in patients with POAG.

Comparing micro-bypass implant + phaco vs phaco in POAG

Funding will support the continued clinical advancement of its lead ocular implant candidate, PA5108, for the reduction of IOP in patients with ocular hypertension and glaucoma.

PolyActiva secures $40 million AUD in Series C funding

Weighing the benefits and trade-offs of preserved versus preservative-free glaucoma treatments is key to optimizing long-term patient care.

The impact of preservatives on the ocular surface in patients with ocular hypertension or glaucoma

NCX 470, Nicox’s lead clinical product candidate, is a novel NO-donating bimatoprost eye drop with a dual mechanism of action (nitric oxide and prostaglandin analogue). 

Nicox releases results from Whistler phase 3b trial in IOP-lowering eye drops

Tapcom is a preservative-free, fixed-combination eye drop of tafluprost 0.0015% and timolol 0.5% for lowering intraocular pressure. 

 Santen receives marketing authorization application approval from NMPA of China for tafluprost/timolol maleate (Tapcom) in patients with open-angle glaucoma

The novel nitric oxide-donating bimatoprost eye drop is being clinically developed for the lowering of IOP in patients with open-angle glaucoma or ocular hypertension.

Nicox announces last patient completed final visit in Whistler Phase 3b clinical trial

ASCRS 2025: Deb Ristvedt, DO, on medications, lasers, and lifestyle in glaucoma management

Deb Ristvedt, DO, moderated a session titled 

, highlighting the rapid evolution of glaucoma treatment paradigms at the 2025 American Society of Cataract and Refractive Surgery annual meeting, held April 25 to 28 in Los Angeles, California.

“This space is so exciting because it's rapidly changing and our mindset is changing,” Ristvedt said. “We're going less drops. We're going earlier in the angle.”

The session emphasized a shift toward earlier intervention and longer-term control to minimize visual field loss. Drug delivery advancements were a central focus. Doug Rhee, MD, presented data on the sustained effects of medications at the trabecular meshwork, noting mechanisms that continue to act even beyond their expected duration. “We have medications in terms of drug delivery that now have more concentration in the eye and provide more stability of IOP 24 hours a day,” Ristvedt highlighted.

Laser therapy is also seeing transformative developments. The discussion revisited the LiGHT trial’s impact on positioning SLT as a first-line treatment. However, new attention was given to direct SLT—a next-generation modality delivering energy translimbally in just 2.6 seconds. “It works through the limbus targeting the trabecular meshwork… getting around the same results as manual SLT,” Ristvedt explained. A key advantage? It eliminates the need for a gonio lens, improving both patient experience and surgeon ergonomics. “It looks like less arching of our bodies. It looks like better setup and better ergonomics.”

Finally, the session examined lifestyle considerations—for both patients and providers. “Our lifestyle is so important when we think about holistically how we're affecting quality of life,” Ristvedt emphasized, underscoring the session’s broader call for sustainable, patient-centric glaucoma care.

Videos

Glaucoma management is shifting toward earlier, drop-sparing interventions using sustained drug delivery and advanced laser technologies that improve outcomes and quality of life for both patients and physicians.

Evolving glaucoma management through the decades: insights from Thomas W. Samuelson, MD

 50th Anniversary, Thomas W. Samuelson, MD, reflects on the evolution of glaucoma treatment over recent decades, highlighting a shift from a traditional stepwise approach of eye drops, laser, and surgery toward a more individualized, interventional strategy that prioritizes patient quality of life and long-term disease management.

The current paradigm often involves managing glaucoma with laser or drops until cataract surgery, at which point a MIGS procedure is incorporated based on disease severity. Samuelson, who is attending surgeon and a founding partner of Minnesota Eye Consultants in Minneapolis, emphasizes that "one of the most important points in the lifetime of a glaucoma patient is when cataract surgery is planned," as it presents an opportunity for simultaneous glaucoma intervention. 

Samuelson highlights the increasing focus on reducing the treatment burden for patients. "We're trying to take the burden of treatment off of patients. We're trying to lessen their load," he explains, noting the role of selective laser trabeculoplasty or direct selective laser trabeculoplasty, depot drug delivery, minimally invasive angle surgeries (MIGS), and goniotomy procedures. These safer interventions help mitigate the risks of medication toxicity, a common issue for long-term glaucoma patients.

Although topical therapy remains an essential component of care, Samuelson views it as increasingly adjunctive: "I'm not one that thinks we can get rid of drops. We're always going to have drops, but drops have become more of an adjunct and supplemental therapy." Many patients can now transition from initial treatment to cataract surgery with a MIGS procedure without reaching the multi-drug regimens that were once standard.

For severe glaucoma, traditional procedures like trabeculectomy and tube shunts remain necessary. However, Samuelson underscores the benefit of reserving these high-risk surgeries for the patients who truly need them. "What used to happen is we'd have to offer people with mild to moderate glaucoma a very aggressive operation, because that's all we had." Now, safer, staged interventions provide a more tailored and patient-friendly approach.

The focus in recent years has shifted to reducing the long-term burden of medical therapy, minimizing the risk of medication toxicity and persistent ocular surface disease. 

Video Series

Glaukos Corporation's COO Chris Calcaterra gives an update on the company's latest  24-month phase 2b data for its iDose TR sustained-release travoprost implant, next steps for securing FDA approval, and his outlook for 2021. 

Glaukos COO shares product updates, 2021 pipeline 

Oluwatosin U. Smith, MD, Glaucoma Associates of Texas, provides an update on optimization and surgical modifications of newer glaucoma surgeries.


Optimizing and modifying newer glaucoma surgeries

Joseph F. Panarelli, MD, associate professor of ophthalmology, NYU Langone Medical Center, shares some clinical pearls for managing masquerade syndromes and determining when it is not glaucoma.

When is it not glaucoma: Masquerade syndromes

Donald L. Budenz, MD, MPH, shares the key takeaways from his Shaffer-Hetherington-Hoskins Lecture, focusing on glaucoma epidemiology, presented during the 2021 Glaucoma 360's 25th Annual Glaucoma Symposium CME. 

Studying glaucoma epidemiology at the center of the Earth 

Robert L. Stamper, MD, discusses the findings of a study analyzing the effects of corneal mechanics on IOP, presented during the virtual Glaucoma 360 meeting.

Analyzing effects of corneal biomechanics on IOP 

Read the article on Dr. William's presentation here

During the 2021 Glaucoma 360 meeting, Ruth D. Williams, MD, speaks on the highlights and key findings from the EAGLE study, which showed clear lens extraction surgery may be a better initial treatment for some glaucoma patients.

Treating PAC, PAC glaucoma with CLE

Tanner Ferguson, MD, an ophthalmology resident at the Cleveland Clinic's Cole Eye Institute, discusses findings from the study "Trabecular Micro-bypass Stent Implantation (iStent)" + Phacoemulsification in PXG: Six-Year Outcomes," during the virtual AAO 2020 meeting. 


Tanner Ferguson, MD, Cole Eye Institute, discusses findings from the study "Trabecular Micro-bypass Stent Implantation (iStent)" + Phacoemulsification in PXG: Six-Year Outcomes," during the virtual AAO 2020 meeting. 

Evaluating long-term safety of micro-bypass implant with phaco in PXG


During AAO 2020, Davinder Grover, MD, MPH, glaucoma specialist, Glaucoma Associates of Texas speaks on the highlights of his presentation regarding outcomes of a 12-year study comparing ab externo vs ab interno xen gel stents in tertiary glaucoma practice.


Davinder Grover, MD, MPH, speaks on the highlights of his presentation regarding outcomes of a 12-year study comparing ab externo vs ab interno xen gel stents in tertiary glaucoma practice. 

Therapeutic Glaucoma

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