Therapeutic advances in glaucoma focus on retinal ganglion cell pathology
August 1st 2015Findings from basic science research elucidating the mechanisms of retinal ganglion cell axon degeneration, regeneration, and death have identified new therapeutic targets for glaucoma that are being investigated in preclinical and clinical studies.
Targeting TGF-beta in different ocular diseases
August 1st 2015A potent and selective transforming growth factor (TGF)-β2 LNA-modified antisense oligonucleotide induces biologic responses consistent with the drug’s expected molecular mechanism of action in different preclinical ocular surface disease models.
TCP gains traction as modality for glaucoma cases with good visual potential
August 1st 2015A proprietary glaucoma device has changed current thinking about cyclophotocoagulation by offering another option in the glaucoma treatment algorithm and allowing earlier laser intervention when medical treatment comes up short.
ECP in refractory glaucoma yields versatility, favorable safety profile with positive results
August 1st 2015Endoscopic cyclophotocoagulation with vitrectomy and pars plana treatment is effective in reducing IOP in patients with ultra-refractory glaucoma, reducing the need for medications and being relatively well tolerated by patients.
Cell count differences in diabetic-related corneas suggests more studies
July 15th 2015An age-stratified analysis of endothelial cell count in diabetic and non-diabetic corneas found no statistically significant difference between the groups. Since diabetes may damage the inner layer of the cornea, other variables that affect cell health must also be evaluated.
Squalamine for AMD ‘robust’ in eyes containing CNV lesions
July 15th 2015Combination treatment with squalamine lactate ophthalmic solution 0.2% and ranibizumab PRN resulted in improved visual function in patients with neovascular age-related macular degeneration compared with treatment with ranibizumab alone.