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Opinion|Videos|January 24, 2025

Study Design for PULSAR and PHOTON Trials for Aflibercept 8 mg

Author(s)John Kitchens, MD, Richard Gale, PhD, MEd, BSc, MBChB, FRCP, FRCOphth, Michael W. Stewart, MD

Panelists discuss how the phase 3 PULSAR and PHOTON trials demonstrated the efficacy of aflibercept 8 mg through a design comparing 12- and 16-week dosing intervals to the aflibercept 2 mg standard 8-week dosing, with primary end points assessing noninferiority in visual acuity maintenance.

Episodes in this series

EP. 1 Evolution of Anti-VEGF Agents and Unmet Needs in Retinal Diseases

EP. 1 Evolution of Anti-VEGF Agents and Unmet Needs in Retinal Diseases

EP. 2 Advantages of the molecular structure of aflibercept

EP. 2 Advantages of the molecular structure of aflibercept

EP. 3 Treat-and-Extend Strategy With Aflibercept

EP. 3 Treat-and-Extend Strategy With Aflibercept

EP. 4 Assessing New Therapies for Retinal Diseases

EP. 4 Assessing New Therapies for Retinal Diseases

EP. 5 Significance of the Higher Molar Dose of Aflibercept 8 mg

EP. 5 Significance of the Higher Molar Dose of Aflibercept 8 mg

EP. 6 Study Design for PULSAR and PHOTON Trials for Aflibercept 8 mg

EP. 6 Study Design for PULSAR and PHOTON Trials for Aflibercept 8 mg

EP. 7 Patient Selection for Aflibercept 8 mg

EP. 7 Patient Selection for Aflibercept 8 mg

EP. 8 Faricimab Molecular Design and Role of Ang-2

EP. 8 Faricimab Molecular Design and Role of Ang-2

EP. 9 Outcomes with Faricimab and Choosing Between the New Therapies

EP. 9 Outcomes with Faricimab and Choosing Between the New Therapies

EP. 10 Safety Profile of New Therapies

EP. 11 Perspectives on the Usefulness of Real-world Data

EP. 11 Perspectives on the Usefulness of Real-world Data

EP. 12 Strategies for Loading Dose Sse for Treatment-Naive and Switch Patients

EP. 12 Strategies for Loading Dose Sse for Treatment-Naive and Switch Patients

EP. 13 Impact of Durable Therapies on Patients and Clinics and Monitoring Strategies

EP. 13 Impact of Durable Therapies on Patients and Clinics and Monitoring Strategies

Video content above is prompted by the following:

Aflibercept 8 mg was evaluated in the PULSAR and PHOTON trials for neovascular age-related macular degeneration and diabetic macular edema. Could you briefly review the design of these trials?

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