Video

ARVO LIVE: Non-viral gene therapy targeting ABCA4 retinopathies

Ophthalmology Times® talked with Theresa Heath, MD, MBA, about Non-viral gene therapy targeting ABCA4 retinopathies at this year's ARVO meeting.

Ophthalmology Times® talked with Theresa Heath, MD, MBA, about Non-viral gene therapy targeting ABCA4 retinopathies at this year's ARVO meeting.

Video transcript

Editor’s note: Transcript lightly edited for clarity.

Theresa Heath, MD, MBA:

I'm really pleased to be here today to give you an update of what we're doing at Intergalactic Therapeutics. We are transforming medicine in nonviral gene therapy and just released our 12-month persistent expression data [inaudible] for lead program called ABCA4-associated retinopathies, or IG-002.

So, the meeting went well. The presentation was really great, we were able to show persistent expression, durability, and more importantly, safety. So, we're really excited to enter IND next year and to start clinical trials next year. I think it's fantastic. With this nonviral gene therapy approach, it can really overcome safety, but more importantly, effectiveness and efficiency for delivering this large payload capacity of the gene to all patients.

What we're also doing is delivering this with a CMC manufacturing process, that allows patient accessibility due to the scalability and the low costs of goods.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times Europe) Anat Loewenstein, MD, shares insights on the real-world results of remote retinal imaging
(Image credit: Ophthalmology Times) Two-wavelength autofluorescence for macular xanthophyll carotenoids with Christine Curcio, PhD
(Image credit: Ophthalmology Times) FLIO and the brain: Making the invisible visible with Robert Sergott, MD
(Image credit: Ophthalmology Times) Structure-function correlates using high-res OCT images with Karl Csaky, MD, PhD
(Image credit: Ophthalmology Times) SriniVas Sadda, MD, on high-res OCT of atrophic and precursor lesions in AMD
(Image credit: Ophthalmology Times) Christine Curcio, PhD, shares histology update supporting review software and revised nomenclature for <3 μm OCT
Steven R. Sarkisian, Jr., MD, ABO, speaks about glaucoma at the 2025 ASCRS annual meeting
© 2025 MJH Life Sciences

All rights reserved.