Frankfurt, Germany—The design of the optic edge seems to be one of the most important factors in the development of posterior capsule opacification (PCO). IOLs with a sharp edge have less PCO regardless of the lens material, according to Thomas Kohnen, MD.
Reposition the IOL first before performing a YAG capsulotomy in instances of symptomatic IOL decentration with concomitant PCO.
Fort Lauderdale, FL—Three-dimensional optical coherence tomography (3-D OCT) imaging and mapping of intraretinal layers are possible using high-speed, ultrahigh-resolution (UHR) OCT, the latest research tool in OCT technology.
Fort Lauderdale, FL—WDR36 is a novel causative gene for adult-onset primary open-angle glaucoma (POAG) that is located at the GLC1G locus. Sharareh Monemi, MD, PhD, and Mansoor Sarfarazi, PhD, explained that this discovery should help in the diagnosis and treatment of glaucoma.
Patients treated with cyclosporine had greater symptomatic improvement compared with controls using preservative-free artificial tears.
Fort Lauderdale, FL—The results from a clinical trial demonstrate that topical moxifloxacin 0.5% ophthalmic solution (Viga-mox, Alcon Laboratories) instilled in a q.i.d. dosing regimen achieves a significantly higher concentration in aqueous humor compared with topical gatifloxacin 0.3% ophthalmic solution (Zymar, Allergan) to provide antibacterial coverage for a broader range of important ocular pathogens, said Joel D. Aronowicz, MD, at the annual meeting of the Association for Research in Vision and Ophthalmology.
Fort Lauderdale, FL—Results from a preclinical study indicate that fluoroquinolones available for ophthalmic use may differ in their effects on corneal healing, said Luis E. Fern?ndez de Castro, MD, at the annual meeting of the Association for Research in Vision and Ophthalmology.
Fort Lauderdale, FL—Supplements of high-dose vitamins C and E and betacarotene may provide some benefit to patients who already have age-related macular degeneration (AMD), said Thomas Friberg, MD.
Uveal melanoma . . . and most solid tumors partially inactivate RB and the tumors proliferate slowly with a low rate of apoptosis.
Cleveland—Verteporfin photodynamic therapy (Visudyne PDT, Novartis Ophthal-mics/QLT Inc.) for symptomatic circumscribed choroidal hemangioma appears to be safe, effective, and associated with potential benefits relative to alternative modalities, said Arun D. Singh, MD.
Los Angeles—The medical management of age-related macular generation (AMD) has progressed by leaps and bounds in a very short space of time and generated a great deal of excitement among retina specialists. In particular, translational research has resulted in a large number of drugs that target choroidal neovascularization (CNV).
Des Plaines, IL—Addition Technology Inc. has seen another boost in sales of its micro-thin prescription inserts (Intacs).
Tarrytown, NY—Regeneron Pharmaceuticals Inc. will begin a phase I trial to evaluate the safety and tolerability of its "VEGF Trap" on patients with the wet form of age-related macular deneration.
Midway through a conference call on July 28 with investors regarding its second-quarter financial results, STAAR Surgical's President and Chief Executive Officer David Bailey interrupted with surprising news: the FDA's Office of Device Evaluation (ODE) had issued an "approvable letter" for its myopic Visian implantable collamer lens (ICL).
Montr?al—Intravitreal injection with the anti-VEGF antibody ranibizumab [(formerly RhuFab) Lucentis, Genentech] has been associated with impressive results in the treatment of minimally classic and occult choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD), according to the 1-year outcomes of a phase III trial.
Selective laser trabeculoplasty (SLT) is a new treatment option for glaucoma that has significant advantages over argon laser trabeculoplasty (ALT) with equal or better outcomes. Although studies are still under way, SLT may have important implications for primary glaucoma therapy.
New Orleans—Results of a retrospective study evaluating outcomes in eyes with an Ahmed Glaucoma Valve (AGV, New World Medical) implanted indicate that the FP7 model with its silicone flexible plate affords better IOP control than the S2 model featuring a rigid polypropylene plate.
Burlington, VT—Early appropriate intervention can make a substantial difference in preventing permanent visual loss or diplopia when faced with a patient who has an orbital compartment syndrome or a white-eyed blowout fracture.
Rockford, IL—A glaucoma shunt that is relatively new to the market is getting very good results in patients whose IOP is uncontrolled despite multiple medications and glaucoma filtering surgeries. The Express Mini-Glaucoma Shunt (Optonol Ltd.) has thus far exceeded the expectations of Edward Yavitz, MD, who said that device is his shunt of choice.
Selective laser trabeculoplasty (SLT) is a new treatment option for glaucoma that has significant advantages over argon laser trabeculoplasty (ALT) with equal or better outcomes. Although studies are still under way, SLT may have important implications for primary glaucoma therapy.
Fort Lauderdale, FL—Latanoprost (Xalatan, Pfizer Ophthalmics) reduces IOP significantly more than does timolol gel-forming solution (GFS), results of a randomized, crossover clinical trial demonstrated.
Indianapolis—The Baerveldt Glaucoma Implant (AMO) overcomes the first hurdle with glaucoma drainage devices by allowing easy placement in the eye in a single quadrant and covers a sufficiently large surface area to obtain safe IOP levels—a good combination in this type of device, according to Louis Cantor, MD.
Philadelphia—The recently approved topical formulation of timolol maleate ophthalmic solution 0.5% (Istalol, Ista Pharmaceuticals) is a noteworthy addition to glaucoma specialists' armamentarium. The ocular penetration of the medication has increased as a result of the addition of potassium sorbate. The increased penetration, in turn, allows for once-daily dosing, a real boon for patient compliance.
The shunt is also novel because it allows surgeon control of the amount of fluid that flows from one area to another, a feat made possible in part by the selection of gold for its construction.
New Orleans—Results of a retrospective study evaluating outcomes in eyes with an Ahmed Glaucoma Valve (AGV, New World Medical) implanted indicate that the FP7 model with its silicone flexible plate affords better IOP control than the S2 model featuring a rigid polypropylene plate.
Fort Lauderdale, FL—In a comparison of prostaglandin analogs in normal-tension glaucoma (NTG), bimatoprost 0.03% (Lumigan, Allergan) lowered IOP significantly more than latanoprost 0.005% (Xalatan, Pfizer Ophthalmics), although both medications significantly reduced IOP from baseline.
Endoscopic cyclophotocoagulation (ECP)—the selective destruction of ciliary processes to decrease the amount of aqueous produced and subsequently lower the IOP—produces reliable, long-term IOP reduction and can also reduce a patient's dependence on glaucoma medications, according to Martin Uram, MD, MPH.
Fort Lauderdale, FL—The fixed combination of dorzolamide hydrochloride-timolol maleate (Cosopt, Merck) and the unfixed combination of latanoprost (Xalatan, Pfizer Ophthalmics) and timolol (Timop-tic, Merck) reduce IOP to a similar degree in patients with glaucoma, according to a small clinical study reported at the Association for Research in Vision and Ophthalmology (ARVO).
Fort Lauderdale, FL—Different strategies have been investigated in retinal ganglion cell (RGC) repair, replacement, and regeneration as therapies for glaucoma; some are promising, others less so. Keith R.G. Martin, MD, MRCP, FRCOphth, described what is happening in this field and some of the new treatments at the annual meeting of the Association for Research in Vision and Ophthalmology.
Boston—Aqueous shunts can offer a very effective modality for controlling IOP in challenging glaucoma cases, and their therapeutic index has improved thanks to innovations in technique and technology introduced based on clinical experience.
