
The 1990s brought a decade of advances in the medical therapy of glaucoma. That decade saw the introduction of a new carbonic anhydrase inhibitor, dorzolamide (Trusopt, Merck); the first prostaglandin, latanoprost (Xalatan, Pfizer); the first alpha-2 agonist, brimonidine (Alphagan, Allergan); and the first fixed-combination carbonic anhydrase inhibitor/beta-blocker, dorzolamide and timolol (Cosopt, Merck).