
Speakers at AAO 2019 event describe journey leading to approval of the first gene therapy for a genetic disease.

Speakers at AAO 2019 event describe journey leading to approval of the first gene therapy for a genetic disease.






ICYMI: Denise Visco, MD, shares the take-home message from her 2019 ASCRS presentation.




The results of widefield epithelial thickness mapping with the Optovue Avanti OCT in eyes with a single mild topographic or tomographic abnormality were similar to normal eyes in myopes, which eases decision making surrounding refractive surgery.


Scleral suturing of a dislocated IOL and exchange of the original lens with an iris-claw IOL were comparable for achieving good visual outcomes with low complication rates.

Researchers demonstrate the feasibility of a surgical method that specifically targets the area of geographic atrophy for RPE replacement.


A new therapy is being investigated in a phase IIb trial to test its safety and effectiveness in patients with moderate-to-severe dry eye disease.

The transzonular injection of a corticosteroid and fluoroquinolone can prevent postoperative infection and inflammation.



Phase III studies of a gene therapy for Leber Hereditary Optic Neuropathy have generated some unexpected positive findings. There is biologic plausibility to explain the data.

Tools for higher-order OCT assessment enable evaluation of features of interest, such as targeted retinal layers or fluid compartments, and may allow for unique characterization of disease phenotypes and treatment response.

Genetic factors play a key role in the onset and progression of diabetic retinopathy, with 65 genes ifentified with several belonging to signaling pathways.

OCT-A detected microcirculatory disturbances during acute post-aural migraine attacks may be an important tool in elucidating the pathophysiological relationship between migraine, aura, and ischemia.





The results of the phase II FILLY study are in agreement with the prior literature on risk factors for GA progression.


Drug combination is considered the gold standard to establish stable mydriasis during cataract surgery with lens implantation.