Publication

Article

Digital Edition

Ophthalmology Times: February 2022
Volume47
Issue 2

Presbyopia: the newest subspecialty?

Author(s):

The future of this age-related condition is bright and in focus.

Presbyopia: the newest subspecialty?

Innovations such as corneal procedures, pharmacologic treatments, scleral procedures, and phakic and intraocular (IOL) lenses abound on the presbyopia landscape.

Article reviewed by Karolinne Maia Rocha, MD, PhD

The presbyopia landscape is crowded to­day with innovations to treat this condition, including corneal procedures, pharmacologic treatments, scleral procedures, and phakic and intraocular (IOL) lenses, according to Karolinne Maia Rocha, MD, PhD, director of cornea and refractive surgery at the Medical University of South Carolina in Charleston.

Corneal procedures

Procedures that are coming down the pike in­clude focal denaturization of collagen fibers that involves use of a femtosecond laser to change the corneal refractive index (laser-induced refractive index change).

Another option is lenticular intrastromal ker­atoplasty, which uses a precut, donor stromal lenticule that is inserted either under a femto­second flap or in a pocket.

Corneal inlays/onlays, presbyopic excimer laser ablation profiles, and modified monovision are also available.

Crystalline lens photodisruption

The femtosecond laser pulses may soften the presbyopic crystalline lens and restore accom­modation.

Pharmacologic therapies

Small aperture optics or the pinhole effect can be achieved by pupil modulation induced pharmacologically. Liquid Vision eye drops (Presbyopia Therapies), CSF-1 ophthalmic solution (Orasis Pharmaceuticals), AGN-190584 (Vuity; Allergan), and FOV Tears (developed by Colombian researcher Felipe Vejarano).

Rocha said she is excited by the prospect of a smaller aperture can improve the depth of focus.

“A pinhole placed in front of the eye can restrict the peripheral vision,” she said. “How­ever, the advantage is that when the pinhole is ‘placed’ at the iris plane, the depth of focus is ex­tended without restricting the peripheral vision.”

The so-called “sweet spot” regarding the size of the natural pupil with constriction may be a range 40% to 50% of the natural pupil size to achieve extended depth of focus without com­promising the distance vision, she said.

Evaluating this approach in the phase 3 GEM­INI 1 clinical trial using AGN-190584 showed that the study patients gained 3 lines of vision 6 hours after drop instillation at day 30. The peak drug effect was at 1 hour after instillation, but the change remained for up to 24 hours.

Other presbyopic approaches include decreasing the lens stiffness and restoring lens elasticity with EV06 (Novartis) and Vision Correction (NanoDrops) causes a change in the refractive index.

Scleral procedures

The laser scleral microporation (LSMTM) proce­dure is performed in 4 quadrants for less than 8 seconds in each quadrant to uncross-link the scleral myofibrils, thereby restoring the mechan­ical efficiency of the natural accommodative mechanism and improving biomechanical mobility to achieve accommodative power, Rocha said.

Intraocular lenses

Several IOL designs are available to treat pres­byopia at the time of lens surgery, ie, accommo­dative, extended-depth-of-focus, small aperture, and multifocal IOLs.

In addition, another procedure, refractive index shaping, will be able to modify monofocal acrylic IOLs to address presbyopia.

“In the future, we will be able to use the femtosecond laser for refractive index shaping, in which [the] laser is applied to an acrylic IOL that selectively changes the polarity and the refractive index,” Rocha said. “This procedure facilitates creation of 3-dimensional structures within an IOL. This takes an acrylic monofocal IOL to a multifocal IOL and vice versa.”

Rocha said she looks forward to a new level of future patient simulation, whereby patients can actually experience the real world through mul­tifocal correction before IOLs are implanted or contact lenses are fitted to facilitate the optimal correction for them.

Karolinne Maia Rocha, MD, PhD
E: karolinnemaia@gmail.com
This article is adapted from Rocha’s presentation at the virtual Real World Ophthalmology meeting. She is a consultant to J&J Vision, Bausch + Lomb, Allergan, Alcon, OysterPoint, LaserACE, Dompe, and Carl Zeiss Meditec.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
At the 2025 ASCRS Annual Meeting, Weijie Violet Lin, MD, ABO, shares highlights from a 5-year review of cross-linking complications
Maanasa Indaram, MD, is the medical director of the pediatric ophthalmology and adult strabismus division at University of California San Francisco, and spoke about corneal crosslinking (CXL) at the 2025 ASCRS annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Taylor Strange, DO, assesses early visual outcomes with femto-created arcuate incisions in premium IOL cases
(Image credit: Ophthalmology Times) ASCRS 2025: Neda Shamie, MD, shares her early clinical experience with the Unity VCS system
Patricia Buehler, MD, MPH, founder and CEO of Osheru, talks about the Ziplyft device for noninvasive blepharoplasty at the 2025 American Society of Cataract and Refractive Surgeons (ASCRS) annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Bonnie An Henderson, MD, on leveraging artificial intelligence in cataract refractive surgery
(Image credit: Ophthalmology Times) ASCRS 2025: Gregory Moloney, FRANZO, FRCSC, on rotational stability
(Image credit: Ophthalmology Times) ASCRS 2025: Steven J. Dell, MD, reports 24-month outcomes for shape-changing IOL
Alex Hacopian, MD, discusses a presbyopia-correcting IOL at the 2025 American Society of Cataract and Refractive Surgeons (ASCRS) annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Parag Majmudar, MD, on bridging the gap between residency and real-world practice
© 2025 MJH Life Sciences

All rights reserved.