Article

Pooled Phase 3 data reports safety, efficacy, reduced treatment burden with faricimab compared with aflibercept for the treatment of nAMD

Author(s):

The AVONELLE-X long-term extension study will continue to evaluate the efficacy, durability, and safety of faricimab in patients with neovascular AMD.

Pooled Phase 3 data reports safety, efficacy, reduced treatment burden with faricimab compared with aflibercept for the treatment of nAMD

The 2-year results of the TENAYA and LUCERNE studies indicated that faricimab (Vabysmo, Genentech), the first intraocular bispecific antibody that inhibits both angiopoietin-2 and vascular endothelial growth factor-A was safe and efficacious for treating neovascular age-related macular degeneration (AMD).

Rishi Singh, MD, FASRS, reported the highlights of the pooled results of the trials on behalf of the study investigators.

TENAYA and LUCERNE were Phase 3 global, randomized, double-masked 112-week trials designed to assess the efficacy, safety, and durability of faricimab in treatment-naïve patients with neovascular AMD.

At week 60, patients in the faricimab arm were treated according to a protocol-driven treat-and-extend–based regimen.

Singh reported that, compared with baseline, gains in vision and decreased central subfield thicknesses following treatment with faricimab out to every-16-week dosing were similar to those achieved with aflibercept (Eylea, Regeneron) with every-8-week dosing with fewer injections, through week 112.

At week 112, more than 60% of patients treated with faricimab achieved every-16-week dosing and about 80% achieved every-12-week dosing or better.

Those who needed treatment every 8 weeks generally had worse baseline ocular characteristics versus extended treatment intervals, he pointed out.

“Early and rapid treatment interval extension with faricimab was associated with stable visual gains and anatomic outcomes through week 112,” Singh commented.

In support of this, the analysis showed that most patients on every-12-week dosing at week 60 achieved every-16-week-dosing at week 112.

Every-8-week dosing was associated with tight anatomic control, and most of these patients on every-8-week dosing at week 60 were on extended dosing intervals at week 112.

Faricimab was well-tolerated with an acceptable safety profile through week 112.

The AVONELLE-X long-term extension study will continue to evaluate the efficacy, durability, and safety of faricimab in patients with neovascular AMD.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times) Dilsher Dhoot, MD, on the evolution of geographic atrophy therapy: where are we now?
(Image credit: Ophthalmology Times Europe) Anat Loewenstein, MD, shares insights on the real-world results of remote retinal imaging
(Image credit: Ophthalmology Times) Two-wavelength autofluorescence for macular xanthophyll carotenoids with Christine Curcio, PhD
(Image credit: Ophthalmology Times) FLIO and the brain: Making the invisible visible with Robert Sergott, MD
(Image credit: Ophthalmology Times) Structure-function correlates using high-res OCT images with Karl Csaky, MD, PhD
(Image credit: Ophthalmology Times) SriniVas Sadda, MD, on high-res OCT of atrophic and precursor lesions in AMD
(Image credit: Ophthalmology Times) Christine Curcio, PhD, shares histology update supporting review software and revised nomenclature for <3 μm OCT
Steven R. Sarkisian, Jr., MD, ABO, speaks about glaucoma at the 2025 ASCRS annual meeting
© 2025 MJH Life Sciences

All rights reserved.