News

Animal models are useful tools for research into the etiology, progression, and treatment of disease. Several animal models have been developed to mimic various features of ophthalmic angiogenesis and many of these models have been used to assess the efficacy and safety of treatment regimens prior to clinical use, as well as to test formulations of drugs and modes of administration.

There are many locations within the eye that an IOL can be placed. Most often, lenses are placed in the bag, but they may be placed in the sulcus, sewn into the posterior chamber, or sewn into or clipped onto the iris. Another location can be in the anterior chamber. Let's look at the evolution of anterior chamber IOLs (AC IOLs) in this month's column.

Nashville, TN-GlazMed International Inc., a non-profit Nashville-based organization dedicated to the dissemination of medical knowledge, technology, and information, announces a collaboration between the United States and Russia-the establishment of the Inter-Regional Association of Ophthalmology.

The growing trend in bimanualmicroincision phacoemulsification has prompted many surgeons to evaluate this new surgical technique. Following are 10 tips for the beginning microincision surgeon. Some of these tips may also help the more experienced surgeon fine-tune his or her approach to bimanual microincision surgery.

Baltimore-The Wilmer Eye Institute's 17th annual Current Concepts in Ophthalmology meeting will feature a presentation by retinal translocation inventor Eugene de Juan Jr., MD, along with 3 days of courses and workshops designed to provide the latest updates in the field. Co-sponsored by Johns Hopkins University School of Medicine, Baltimore, and Ophthalmology Times, the meeting will convene Dec. 2 to 4.

New Orleans-"Hot-off-the-press" results from the 2004 International Society of Refractive Surgery of the American Academy of Ophthalmology (ISRS/AAO) refractive surgery survey are being examined to determine what constitutes standard of care, said Richard J. Duffey, MD, at the opening day session of the refractive subspecialty day meeting.

Irvine, CA-For years, Roger F. Steinert, MD, struggled to carve out time to explore his theories while tending to patients and teaching students in Boston.

Paris-Available scientific information provides ample evidence that bimanual microincision cataract surgery (MICS) is at least as safe and effective in many respects compared with coaxial phacoemulsification.

Iowa City, IA-Investigators here have identified subtle gene defects that underlie some cases of age-related macular degeneration (AMD), providing clues to the origin and possibly treatment of the condition, but at the same time suggesting a broad molecular-biological diversity.

Lexington, KY-Mice deficient in monocyte chemoattractant protein-1 (Ccl-2) or its cognate C-C chemokine receptor-2 (Ccr-2) provide a high-fidelity model of atrophic and neovascular age-related macular degeneration (AMD), and studies performed with those animals so far implicate a role for macrophage dysfunction in AMD pathogenesis, said Jayakrishna Ambati, MD.

Iowa City, IA-Investigators here have identified subtle gene defects that underlie some cases of age-related macular degeneration (AMD), providing clues to the origin and possibly treatment of the condition, but at the same time suggesting a broad molecular-biological diversity.

Unless action is taken, resident training and patient care may suffer

San Diego-The WaveScan System (VISX) may be a valuable method to measure refractions accurately and objectively before LASIK.

The fourth-generation fluoroquinolones gatifloxacin 0.3% (Zymar, Allergan) and moxifloxacin 0.5% (Viga- mox, Alcon Laboratories) provide safe, potent, and broad-spectrum coverage against bacterial pathogens that are important in post-refractive surgery infections, and based on that profile should be considered the treatment of choice for antimicrobial prophylaxis in patients undergoing excimer laser refractive procedures, agree Daniel S. Durrie, MD, and William Trattler, MD.

How nonsteroidal anti-inflammatory agents (NSAIDs) and anti-infective drugs are used during cataract and refractive procedures varies depending with the procedure and the physician performing it. A few high-volume refractive surgeons explained their regimens and why use of the drugs differs.

New York-Aqueous misdirection is "a rare, but serious complication of intraocular surgery" that requires immediate attention to prevent lasting damage, Celso Tello, MD, told participants at the Glaucoma 2004 meeting here.

The nomenclature and etiology of "dermoid" tumors and fatty lesions of the orbit and ocular adnexa have created longstanding confusion.

A fourth-nerve palsy is a common cause of acquired vertical diplopia in the adult. These patients typically complain of vertical diplopia and tilting (torsion) of objects. The history and exam should focus on any other neurologic signs or symptoms, recent head trauma, vasculopathic risk factors, and prior symptoms suggestive of a congenital or long-standing palsy.

Cleveland-Comprehensive ophthalmologists Richard E. Gans, MD, FACS, and Shari Martyn, MD, have joined the Cleveland Clinic Cole Eye Center.

Santa Barbara, CA-Miravant Medical Technologies will launch an additional clinical trial in an effort to meet the FDA's conditions for final marketing approval of its tin ethyl etiopurpurin (SnET2).

Washington, DC-Pfizer Ophthalmic's patented formulation of latanoprost (Xalatan) is safe from competition for now, after the National Institutes of Health (NIH) has refused to step in and license generic versions.

Miami-Integrin antagonists may offer a potent alternative strategy for the treatment of sight-threatening eye diseases associated with angiogenesis, said Martin Friedlander, MD, PhD, at Angiogenesis 2004.

San Diego-An evaluation of the first group of patients to undergo conductive keratoplasty (CK) performed by Ronald Friedman, MD, indicates that the procedure can be safely used to treat hyperopia and presbyopia and is easily introduced into an average-volume practice with a refractive and cataract base.

Three months after the . . . procedure, there was a substantial reduction in higher-order aberrations, coma, and spherical aberration.

From a patient's perspective, using a non-steroidal anti-inflammatory drug (NSAID) before and after cataract or refractive surgery can help to ease pain, swelling, and irritation, and accelerate the return of visual acuity. From a surgeon's perspective, using an NSAID reduces surgical complications and makes surgery easier: it keeps the pupils larger, allowing for quicker and less traumatic procedures. It also prevents cystoid macular edema (CME) and reduces the incidence of striae because it suppresses pain and, therefore, the patient's tendency to squeeze/rub the eyes post-surgery. This article will examine the different classes of NSAIDs, compare their analgesic and anti-inflammatory activity, and determine the potency of different NSAIDs.

Plymouth Meeting, PA-Genaera Corp. is expanding its third U.S. phase II clinical trial of squalamine, its small-molecule, anti-angiogenic drug for the treatment of wet age-related macular degeneration (AMD).

San Diego-Cold ultrasound technology [WhiteStar, Advanced Medical Optics Inc. (AMO)] allows the efficient removal of all densities of cataracts and is as safe as a pulsed laser microincision phacoemulsification system. A major advantage of the cold ultrasound system is that it dramatically reduces the phacoemulsification time compared with laser phacoemulsification.