News

While early data show that vascular endothelial growth factor(VEGF) may prevent vision loss and even produce gains in patientswith wet age-related macular degeneration (AMD), much remains to belearned about the class of VEGF inhibitors. Only one drug in thisclass, pegaptanib sodium (Macugen, OSI/Eyetech Pharmaceuticals) hasbeen approved, while others are in the clinical trials pipeline.

For thousands of ophthalmologists and vision researchers, a springtrip to Fort Lauderdale, FL, is an annual tradition that mixes alittle bit of sunshine with a whole lot of academics. Thattradition continues this year, with the 2006 Association forResearch in Vision and Ophthalmology (ARVO) annual meeting fromSunday, April 30 to Thursday, May 4.

For thousands of ophthalmologists and vision researchers, a springtrip to Fort Lauderdale, FL, is an annual tradition that mixes alittle bit of sunshine with a whole lot of academics. Thattradition continues this year, with the 2006 Association forResearch in Vision and Ophthalmology (ARVO) annual meeting fromSunday, April 30 to Thursday, May 4.

Baltimore?Photodynamic therapy (PDT) has been the mainstay of treatment for choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD) until recently when combination therapies (PDT and anti-vascular endothelial growth factor [VEGF]) agents started to be explored.

Fort Lauderdale, FL?For thousands of ophthalmologists and vision researchers, a spring trip to Fort Lauderdale, FL, is an annual tradition that mixes a little bit of sunshine with a whole lot of academics. That tradition continues this year, with the 2006 Association for Research in Vision and Ophthalmology (ARVO) annual meeting scheduled for Sunday, April 30 to Thursday, May 4.

New York?The Scleral Spacing Procedure (SSP) for Presbyopia with PresVIEW Scleral Implants (PSI) (Refocus Group Inc., formerly PresbyCorp) provides significant improvement in near visual acuity (VA) and no change in the uncorrected distance VA, according to Barrie D. Soloway, MD, FACS.

New York?When glaucoma suddenly stole vision from Minnesota Twins' Kirby Puckett's right eye and forced his retirement from Major League Baseball in 1996, it offered those in ophthalmology a remarkable opportunity to increase awareness about the disease.

For almost 2 years, I have pioneered a change in phaco needleconfiguration to improve the safety of cataract surgery. The DeweyRadius Tip, manufactured by Microsurgical Technologies (MST,Redmond, WA) is a standard phaco needle with a simpleexception-no sharp edges. This rounded design can be appliedto any phaco needle of standard gauge, bevel, or bend.

Clowning around

When Stephen R. Powell, MD, is spreading cheer throughout the community, his patients usually do not recognize him. Why? Dr. Powell moonlights as a unicycle-riding clown.

Atlanta?A 6-year study confirms the safety of dual-laser blepharoplasty for aesthetic rejuvenation of the upper and lower eyelids. Describing a series of 320 blepharoplasties, Harley Freiberger, MD, a dermatologic cosmetic surgeon in Los Angeles, reported that no permanent complications were observed, and that lesions healed rapidly and patients were quickly able to return to normal activity.

Indianapolis?Squalamine lactate (Evizon, Genaera) seems to be safe and effective when administered with photodynamic therapy (PDT) using verteporfin (Visudyne, Novartis Ophthalmics/QLT Inc.) to patients with wet age-related macular degeneration (AMD), according to Thomas A. Ciulla, MD.

Cambridge, England?Research published in the January issue of the British Journal of Ophthalmology found not only a strong association between pack years of cigarette smoking and age-related macular degeneration (AMD) but also an increased risk of AMD in nonsmokers exposed to passive smoking.

Montr?al?A modified version of the Amsler grid, with a backlit screen and other changes, improves detection of scotomas and is easier for patients and clinicians to use, according to designer Elie Khouri, MD, a Montr?al ophthalmologist.

Bethesda, MD?The Age-Related Eye Disease Study (AREDS) indicatedthat supplementation with micronutrients has a protective effect inpreventing the development of advanced stages of age-relatedmacular degeneration (AMD). Emily Y. Chew, MD, reviewed thefindings of the role of micronutrients for the treatment of AMD.

Boston?Ruboxistaurin mesylate (Arxxant, Eli Lilly), an investigational drug that is an oral protein kinase C (PKC) beta inhibitor, reduced the occurrence of sustained moderate vision loss by 40% in patients with moderately severe to very severe nonproliferative diabetic retinopathy, reported Lloyd P. Aiello, MD, PhD.

Boston?The 12-month results of two randomized clinical trials of ranibizumab (Lucentis, Genentech) indicate that the drug shows encouraging signs of activity against vascular endothelial growth factor (VEGF) in age-related macular degeneration (AMD).

Cleveland?Anti-vascular endothelial growth factor (VEGF) therapy has been validated as the foundation treatment for age-related macular degeneration (AMD), stated Lawrence J. Singerman, MD, who provided an update on pegaptanib sodium (Macugen, OSI Pharmaceuticals/Eyetech Pharmaceuticals).

Miami?Optical coherence tomography (OCT) can be a valuable tool for evaluating the status of choroidal neovascularization (CNV) in patients with wet age-related macular degeneration (AMD), particularly when new drugs are being used to treat the disease, said Philip J. Rosenfeld, MD, PhD, associate professor of ophthalmology, Bascom Palmer Eye Institute, Miami.

New York?Anecortave acetate (Retaane 15 mg suspension, Alcon Laboratories) seems to be safe and effective for the treatment of exudative age-related macular degeneration (AMD) compared with photodynamic therapy (PDT) with verteporfin for injection (Visudyne, Novartis Ophthal-mics/QLT Inc.).

Frankfurt, Germany?Twenty-three gauge vitrectomy instrumentation has become available and offers surgeons an alternative to 25-gauge instruments. Claus Eckardt, MD, looked at the pros and cons of these smaller instruments.