Companies announce presentations at upcoming 2025 ARVO Annual Meeting

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The 2025 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting will take place May 4-8, 2025, in Salt Lake City, Utah. Ahead of this exciting meeting, several companies have announced that data from clinical trials will be shared at this event.

As researchers prepare for their presentations, we are highlighting some of the scheduled sessions that will share important data and research from around the globe.

Note: The following list of presentations is in alphabetical order by company and will be updated as more information becomes available.

Alkeus Pharmaceuticals

The company will share results from its clinical studies of investigational oral gildeuretinol for the treatment of Stargardt disease (TEASE) and geographic atrophy secondary to age-related macular degeneration (SAGA) at the 2025 ARVO annual meeting.¹⁰

• Safety and Efficacy of Oral Gildeuretinol for Stargardt Disease: TEASE-1 Trial
  • Presented by Benjamin Bakall, MD, PhD on Monday, May 5, 2025 at 4:30 PM to 4:45 PM MT
• Oral Gildeuretinol Treatment in Geographic Atrophy Secondary to AMD in the SAGA Trial: Safety, Efficacy and Patient-reported Outcomes
  • Presented by David Boyer, MD, on Tuesday, May 6, 2025 at 4:45 PM to 5:00 PM MT

Ashvattha Therapeutics

Jeff Cleland, PhD, CEO of Ashvattha Therapeutics, will present a poster entitled “Subcutaneous Migaldendranib Reduces Anti-VEGF Treatment Burden: A Unique Therapeutic Platform to Treat Retinal Vascular Disease” during the poster session on Wednesday, May 7, 2025, from 2:00-3:45pm MT.

This poster will highlight Phase 2 results for migaldendranib (MGB), Ashvattha’s investigational subcutaneous treatment for wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME). It was previously announced that the phase 2 clinical data demonstrated that MGB administration lowered production of subretinal fluid, reducing or eliminating the need for intravitreal anti-VEGF treatment in both the study eye and fellow eye in wet AMD and DME subjects with bilateral disease.¹

Avirman Biopharma Inc.

The company will have presentations that highlight its advancing ocular gene therapy, including the development of its proprietary VSaf AAV manufacturing platform and therapeutic candidate ABI-201, a single AAV vector carrying 3 functional genes to treat dry AMD.⁸

• A Fast and Robust VSaf AAV Platform Technology for Producing High Quality and Yield of AAV Vectors for Ocular Gene Therapy
  • Presented by Shengjiang Liu, PhD on Wednesday, May 7, 2025 from 2:15 PM to 2:30 PM MT.
• Protective Efficacy of ABI-201 in a Sodium Iodate-Induced Retinal Damage Model of Dry AMD in Non-Human Primates
  • Presented by Sameera Peraramelli, PhD on Monday, May 5, 2025 from 3:00 PM to 4:45 PM MT
• Advancing Retinal Disease Research: The Sodium Iodate NHP Model for Translational Therapeutic Evaluation
  • Presented on May 4, 2025 from 1:00 PM to 1:30 PM MT

Beacon Therapeutics

At the meeting, Beacon Therapeutics is set to present 6-month interim safety and efficacy results from the Phase 2 DAWN trial of the Company's lead program, laru-zova (laruparetigene zovaparvovec), in patients with X-linked retinitis pigmentosa (XLRP). The presentation is titled, "Subretinal gene therapy laru-zova (AGTC-501) for X-linked retinitis pigmentosa (XLRP): Phase 2 DAWN preliminary month 6 results" and will be given by Mark Pennesi, MD, PhD, FARVO, on Tuesday, May 6, 2025.¹¹

Clearside Biomedical

Six abstracts related to Clearside’s suprachoroidal drug delivery platform have been accepted for presentation at the 2025 ARVO meeting.² These presentations are as follows:

• Top Line Results from ODYSSEY: A Phase 2b Study of Suprachoroidally Administered CLS-AX in Participants with Neovascular Age-related Macular Degeneration
  • Presented by Robert Wang on Thursday, May 8, 2025, from 3:00 pm - 3:15 pm MT.
• Suprachoroidal CLS-AX (Axitinib Injectable Suspension) Offers Durability, Safety, and Therapeutic Potential for Neovascular Age-Related Macular Degeneration (nAMD) Patients: Preclinical and Clinical Corroboration
  • Posterboard number A0125 presented by Viral Kansara, PhD on Wednesday, May 7, 2025, from 10:15 am - 12:00 pm MT
• The Evolving Role of Suprachoroidal Drug Delivery in Macular Diseases: A Decade-Long Literature Review
  • Posterboard number B0517 presented by Victor Chong, MD, MBA on Monday, May 5, 2025, from 8:30 am - 10:15 am MT
• Validation of Suprachoroidal Injection Training Program with a Synthetic Eye Model
  • Posterboard number B0415 presented by Chen-rei Wan on Thursday, May 8, 2025, from 8:00 am - 9:45 am MT
• Dispensability Analysis of Suspension Formulations
  • Posterboard number B0515 presented by Darrin Rountree, MS on May 5, 2025, from 8:30 am - 10:15 am MT
• Novel Deep Learning Algorithm for Suprachoroidal Space Segmentation and Measurement in Optical Coherence Tomography
  • Posterboard number A0229 presented by Oluwagbemisola Aderibigbe on May 4, 2025, from 1:00 pm - 2:45 pm MT

Doheny Eye Institute

Doheny Eye Institute announced that more than 25 of its scientists and clinician-scientists will present their latest research at the 2025 ARVO Annual Meeting. In addition to a strong lineup of presenters, Doheny will also be well represented as SriniVas R. Sadda, MD, closes out his term as president of ARVO at the culmination of the 2025 meeting.⁹

A complete list and schedule for all the Doheny Eye Institute and UCLA Stein Eye Institute research presentations is available online.⁹

EyePoint Pharmaceuticals

Data from EyePoint has been accepted for presentation at the upcoming 2025 ARVO Annual Meeting. The company plans to showcase its clinical trial datasets for is phase 2 VERONA trial and phase 2 DAVIO 2 trial, which across multiple indications saw continued safety and efficacy, as well as the program’s de-risked study designs that reflect real-world patient populations.³

Eyestem Research

Eyestem has recently shared that all patients across 3 cohorts in the company’s phase 1 trials of its investigational drug, Eyecyte-RPE, in patients with geographic atrophy (GA) secondary to dry age-related macular degeneration (AMD) were dosed without any serious adverse events. The first 6 patients showed an average 14.9-letter gain in ETDRS vision tests within 4–6 months, with early signs of disease reversal seen in some retinal scans. Data from this trial will be presented at the ARVO meeting.⁴

Iolyx Therapeutics

The company will present new developments and updates on its lead candidate, ILYX-002, for immune-driven dry eye disease (DED) from a recent Phase 2 clinical trial, ILYX-002-201. The presentation will take place during the Dry Eye: Clinical Aspects II session on May 8, 2025, 8:00 am – 9:45 am MST. Dr. Mark Hinds, principal investigator for the ILYX-002-201 trial, will be the presenter on the company’s behalf.⁵

Luxa Biotechnology

Luxa Biotechnology said it will present clinical results for its investigational dry age-related macular degeneration (AMD) cell therapy candidate, RPESC-RPE-4W, at the 2025 ARVO Annual Meeting. The data from cohort 1 of its phase 1/2a clinical trial evaluating RPESC-RPE-4W, a retinal pigment epithelium (RPE) cell therapy derived from adult retinal pigment epithelial stem cells (RPESCs).¹³

Nanoscope Therapeutics

The company is scheduled to participate at both the Eyecelerator and the 2025 ARVO annual meetings. Nanoscope's presentations will be centered around 126-week outcomes following treatment with its MCO-010 optogenetic therapy for retinitis pigmentosa (RP), the first and only therapy shown to restore vision in advanced RP patients via a one-time, standard intravitreal injection.¹⁴

Ocular Therapeutix

Ocular Therapeutix will present information at the meeting in Fort Lauderdale regarding the axitinib intravitreal hydrogel clinical trials, the use of its candidate OTX-TKI for diabetic retinopathy, and the HELIOS clinical trial for diabetic retinopathy.¹⁵

Opus Genetics

Three abstracts on the company’s investigational gene therapy candidates have been accepted for presentation at the ARVO 2025 Meeting. The abstracts feature 12-month data from the first 3 adult patients in the ongoing Phase 1/2 trial of OPGx-LCA5, as well as preclinical results on OPGx-MERTK and OPGx-RDH12.⁶

• Evaluation of MERTK gene therapy in RCS rats following a single bilateral subretinal injection
  • Presented by Mayur Choudhary, PhD, on May 8, 2025, from 11:45 am to 1:30 pm MT.
• Evaluation of ocular tolerability of OPGx-RDH12 by subretinal delivery in cynomolgus primates
  • Presented by Ash Jayagopal, PhD, on May 5, 2025, from 8:30 am to 10:15 am MT
• LYNX-1 Phase 3 trial of the safety and efficacy of phentolamine ophthalmic solution for the treatment of reduced mesopic low contrast vision: A subset analysis of keratorefractive subjects
  • Presented by Kostas Charizanis, PhD on May 4, 2025 from 8:00 am to 9:45 am MT

Stealth BioTherapeutics

The company's data will feature in several presentations at the ARVO annual meeting. These include new data on bevemipretide, the company's next-generation ocular topical investigational medicine, including protective effects observed in models of dry age-related macular degeneration (AMD) and glaucoma, and preclinical toxicology and exposure data informing the company's planned Phase 1 study.¹²

TMR Pharma N.V.

TME Pharma N.V. and the Singapore Eye Research Institute (SERI) will present a poster highlighting data from preclinical studies performed with mNOX-E36 by SERI at the ARVO Annual Meeting. Preclinical data show that mNOX-E36 is as efficacious as standard-of-care mitomycin C (MMC) at attenuating postoperative inflammation and scarring (fibrosis) following glaucoma filtration surgery (GFS).⁷

The poster will be titled “Inhibition of MCP-1 with mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery” and will be posterboard number A0418. It will be presented by Professor Tina Wong on May 06, 2025, from 8:30 am – 10:15 am MT.⁷

Reference:

1. Ashvattha Therapeutics to Present at ARVO, Retina World Congress, and AOS Annual Meeting. Ashvattha Therapeutics. April 15, 2025. Accessed April 16, 2025. https://www.globenewswire.com/news-release/2025/04/15/3061682/0/en/Ashvattha-Therapeutics-to-Present-at-ARVO-Retina-World-Congress-and-AOS-Annual-Meeting.html

2. Clearside Biomedical Announces Six Abstracts Accepted for Presentation at Association for Research in Vision and Ophthalmology (ARVO) 2025 Meeting. Clearside Biomedical. March 24, 2025. Accessed April 16, 2025. https://www.globenewswire.com/news-release/2025/03/24/3047721/0/en/Clearside-Biomedical-Announces-Six-Abstracts-Accepted-for-Presentation-at-Association-for-Research-in-Vision-and-Ophthalmology-ARVO-2025-Meeting.html

3. EyePoint Reports Fourth Quarter and Full-Year 2024 Financial Results and Highlights Recent Corporate Developments. EyePoint Pharmaceuticals. March 5, 2025. Accessed April 16, 2025. https://www.globenewswire.com/news-release/2025/03/05/3037277/0/en/EyePoint-Reports-Fourth-Quarter-and-Full-Year-2024-Financial-Results-and-Highlights-Recent-Corporate-Developments.html

4. Eyestem’s Eyecyte-RPE™ Trial Shows Vision Rescue for Geographic Atrophy Patients. Eyestem Research. April 15, 2025. Accessed April 16, 2025. https://www.businesswire.com/news/home/20250414346272/en/Eyestems-Eyecyte-RPE-Trial-Shows-Vision-Rescue-for-Geographic-Atrophy-Patients

5. Iolyx Therapeutics to Present at Multiple Upcoming Ophthalmology Conferences. Iolyx Therapeutics, Inc. March 12, 2025. Accessed April 16, 2025. https://www.globenewswire.com/news-release/2025/03/12/3041356/0/en/Iolyx-Therapeutics-to-Present-at-Multiple-Upcoming-Ophthalmology-Conferences.html

6. Opus Genetics Announces Presentations at Association for Research in Vision and Ophthalmology (ARVO) 2025 Meeting. Opus Genetics. March 5, 2025. Accessed April 16, 2025. https://www.globenewswire.com/news-release/2025/03/05/3037375/0/en/Opus-Genetics-Announces-Presentations-at-Association-for-Research-in-Vision-and-Ophthalmology-ARVO-2025-Meeting.html

7. TME Pharma Announces Filing of Patents for Use of CCL2 Inhibitor NOX-E36 in Ophthalmology and Presentation at ARVO 2025 of Preclinical Data Showing Benefit in Glaucoma Filtration Surgery. TMR Pharma N.V. March 13, 2025. Accessed April 16, 2025. https://www.businesswire.com/news/home/20250313839845/en/TME-Pharma-Announces-Filing-of-Patents-for-Use-of-CCL2-Inhibitor-NOX-E36-in-Ophthalmology-and-Presentation-at-ARVO-2025-of-Preclinical-Data-Showing-Benefit-in-Glaucoma-Filtration-Surgery

8. Avirmax Biopharma Inc. to Present at the 2025 ARVO Annual Meeting in Salt Lake City. Avirmax Biopharma Inc. April 23, 2025. Accessed April 24, 2025. https://www.prnewswire.com/news-releases/avirmax-biopharma-inc-to-present-at-the-2025-arvo-annual-meeting-in-salt-lake-city-302436454.html

9. Doheny Eye Institute Announces Upcoming Presentations at the Association for Research in Vision and Ophthalmology 2025 Annual Meeting. Doheny Eye Institute. April 16, 2024. Accessed April 24, 2025. https://www.globenewswire.com/news-release/2025/04/16/3062586/0/en/Doheny-Eye-Institute-Announces-Upcoming-Presentations-at-the-Association-for-Research-in-Vision-and-Ophthalmology-2025-Annual-Meeting.html

10. Alkeus Pharmaceuticals Announces Presentations of Gildeuretinol Data During the Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting May 4-8, 2025. Alkeus Pharmaceuticals. April 24, 2025. Accessed April 25, 2025. https://www.globenewswire.com/news-release/2025/04/24/3067634/0/en/Alkeus-Pharmaceuticals-Announces-Presentations-of-Gildeuretinol-Data-During-the-Research-in-Vision-and-Ophthalmology-ARVO-2025-Annual-Meeting-May-4-8-2025.html

11. Beacon Therapeutics Announces ARVO 2025 Presentation on Preliminary 6-Month Data from its Phase 2 DAWN Trial of laru-zova in Patients with X-linked Retinitis Pigmentosa (XLRP). Beacon Therapeutics. April 24, 2025. Accessed April 25, 2025. https://www.prnewswire.com/news-releases/beacon-therapeutics-announces-arvo-2025-presentation-on-preliminary-6-month-data-from-its-phase-2-dawn-trial-of-laru-zova-in-patients-with-x-linked-retinitis-pigmentosa-xlrp-302437302.html

12. Stealth BioTherapeutics to Present New Bevemipretide Data at ARVO Annual Meeting. Beacon Therapeutics. April 24, 2025. Accessed April 25, 2025. https://www.prnewswire.com/news-releases/stealth-biotherapeutics-to-present-new-bevemipretide-data-at-arvo-annual-meeting-302436558.html

13. Luxa Biotechnology to present interim clinical data for dry AMD cell therapy at ARVO 2025. Luxa Biotechnology. April 28, 2025. Accessed April 28, 2025. https://www.koreabiomed.com/news/articleView.html?idxno=27413

14. Nanoscope Therapeutics Announces Participation at Eyecelerator and ARVO 2025 Annual Meetings. Nanoscope Therapeutics. April 25, 2025. Accessed April 28, 2025. https://firstwordpharma.com/story/5953086

15. Ocular Therapeutix™ to Participate in Upcoming Investor and Scientific Conferences. Ocular Therapeutix. April 29, 2025. Accessed April 29, 2025. https://www.globenewswire.com/news-release/2025/04/29/3070022/0/en/Ocular-Therapeutix-to-Participate-in-Upcoming-Investor-and-Scientific-Conferences.html