Animal knockout models offer platform for AMD studies

Lexington, KY-Mice deficient in monocyte chemoattractant protein-1 (Ccl-2) or its cognate C-C chemokine receptor-2 (Ccr-2) provide a high-fidelity model of atrophic and neovascular age-related macular degeneration (AMD), and studies performed with those animals so far implicate a role for macrophage dysfunction in AMD pathogenesis, said Jayakrishna Ambati, MD.