News

Orlando-The CRS-Master (Carl Zeiss Meditec) ablation profile design workstation is a "best of breed" platform for customized ablations because it integrates wavefront, topography, and clinical data for the individual patient while giving the surgeon control in designing the laser treatment, said Dan Z. Reinstein, MD, FRCSC.

Orlando-Six-month results from an FDA clinical trial indicate that customized wavefront-guided LASIK for treatment of myopia with the WavePrint system (VISX) is associated with safe and effective outcomes exceeding FDA targets. The wavefront-guided LASIK is also effective for minimizing increases in higher-order aberrations that can accompany conventional LASIK.

Orlando-Argon laser trabeculoplasty (ALT) can achieve substantial IOP reductions in patients with open-angle glaucoma that is refractory to medical therapy. In addition to efficacy, the cost of the procedure compares favorably with medical treatments, which tend to be substantially more costly over time, according to Karen M. Joos, MD, PhD.

The sky's the limit

Fort Bragg, NC-As a reward for helping a colleague with a difficult postoperative situation, Robert K. Maloney, MD, got thrown out of an airplane, literally.

Salt Lake City-Research from the Moran Eye Center, University of Utah School of Medicine, Salt Lake City, showed that low ocular levels of the antioxidants lutein and zeaxanthin could contribute to age-related macular degeneration (AMD).

Orlando-Advancements in refractive surgery were the talk of Nidek's workshop on customized ablation at the American Academy of Ophthalmology (AAO) annual meeting here last fall. The symposium was intended as a forum for ophthalmologists to gain a better understanding of the technology available to them.

FDA Briefs

FDA OKs trials of laser reversal of presbyopia

New York-Pfizer Inc. and Eyetech Pharmaceuticals Inc. will jointly develop and commercialize Eyetech's pegaptanib sodium (Macugen) as a potential treatment for age-related macular degeneration (AMD) and diabetic macular edema (DME).

Indianapolis-Eli Lilly and Co. will delay the submission of its ruboxistaurin for the treatment of diabetic retinopathy and diabetic macular edema (DME) after two clinical trials failed to achieve satisfactory results on disease progression.

Orlando-A carefully designed comparison study has shown that the fixed combination of dorzolamide-timolol (Cosopt, Merck) is at least as effective as its concomitant components and might provide better trough control in some patients, said Stanley J. Berke, MD, FACS.

Orlando-The incidence of iris hyperpigmentation associated with unoprostone isopropyl ophthalmic solution 0.15% (Rescula, Novartis) was about 1% in two long-term studies, a rate that compares favorably with the incidence of 10% to 20% associated with latanoprost ophthalmic solution (Xalatan, Pharma-cia) in similar patient populations, reported Bernard E. McCarey, PhD.

Bimatoprost 0.03% (Lumigan, Allergan) offers more efficacy than latanoprost 0.005% (Xalatan, Pharmacia) for lowering elevated IOP and is similarly well tolerated, according to the results of a 6-month, multicenter, randomized, double-masked study.

Orlando-Although challenging to set up and conduct, studies that check glaucoma patients' IOP at intervals around the clock for 24 hours or longer provide valuable data about the ability of a medication to lower IOP and reduce fluctuation.

Orlando-Optical coherence tomography (OCT, Carl Zeiss Meditec) offers supe-rior sensitivity and specificity in detect-ing glaucoma and its progression, according to Boston glaucoma specialist Joel S. Schuman, MD.

Orlando-In scanning laser polarimetry (SLP), eye-specific correction of corneal polarization axis and magnitude can be obtained for the quantitative assessmentof the peripapillary retinal nerve fiber lay-er (RNFL) if macular-based strategies are used in eyes free of macular pathology, according to glau-coma specialist David S. Greenfield, MD.

Brimonidine tartrate 0.15% (Alphagan P, Allergan) is a "new and improved" version of brimonidine 0.2% (Alphagan, Allergan). It continues to have an efficacy profile similar to the one ophthalmologists have grown used to with brimonidine 0.2%.

Orlando-Optic nerve head (ONH) imaging forms an essential part of the management of suspected glaucoma, as well as in patients with established glaucomatous visual field loss, according to a London glaucoma specialist.

Fullerton, CA-An analysis of tear film function after LASIK and LASEK indicates patients fared equally in the two groups when LASEK was performed for high myopia.Tear film dysfunction seems to be best correlated to the depth of the ablation and not flap dimension, according to Robert Lingua, MD.