News

Melville, NY—OSI Pharmaceuticals has completed its $935 million acquisition of Eyetech Pharmaceuticals Inc. after reviewing recent data by Eyetech competitor Genentech Inc.

The Scoring Tool for Assessing Risk (STAR) is intended for use in patients with untreated ocular hypertension. It is a cardboard, slide rule-type device featuring two sliding bars (A and B) and three windows.

The promise of 2004, that new anti-vascular endothelial growth factor (VEGF) treatments for age-related macular degeneration (AMD) be developed, came to fruition in 2005, much to the excitement of ophthalmologists. These emerging treatments for AMD took center stage this year and resulted in numerous ideas about the effect of the pharmaceutical advancements and their impact on other retinal diseases.

A newly developed glaucoma risk calculator will enhance the management of untreated ocular hypertension, said Robert N. Weinreb, MD, director, Hamilton Glaucoma Center, and distinguished professor of ophthalmology, University of California, San Diego (UCSD).

Montr?al—The benefits observed in patients with age-related macular degeneration (AMD) after 1 year of treatment with pegaptanib sodium (Macugen, OSI/Eyetech Pharmaceuticals) continued into the second year of treatment with pegaptanib sodium and surpassed those outcomes achieved with 1 year of treatment followed by usual care and 2 years of usual care, according to Donald J. D'Amico, MD.

Toulouse, France—With lengthening follow-up, the posterior chamber implantable collamer lens (ICL) (STAAR Surgical) continues to be associated with encouraging results in the management of refractive amblyopia in children who have not had a response to conventional therapy with contact lenses or spectacles, said Laurence C. Lesueur, MD.

Refractive IOLs, fine-tuning of excimer laser surgery, and shifts in the choices of refractive surgeries, among other developments, have all been highlighted as the primary advances in 2005.

Advances in techniques and technology for cataract surgery and IOL implantation have continued through the past year. Those innovations combined with changes in reimbursement have improved the practice setting, contributed to an overall air of increased optimism among ophthalmologists, and have made the contemporary era of cataract surgery more of a golden age than ever before, said I. Howard Fine, MD, reflecting on the state of cataract surgery as the year 2005 nears its end.

Beginning in 2006, ophthalmologists board-certified after July 1, 1992 will transition to new Maintenance of Certification (MOC) requirements set by the American Board of Ophthalmology (ABO), which stresses lifelong learning and ongoing improvement.

Houston—Filtering bleb encapsulation after trabeculectomy seems to respond well to tapering topical corticosteroids alone or in conjunction with IOP-lowering agents. Withdrawing steroids appeared beneficial for lowering the IOP compared with continuing the use of steroids to prevent inflammation, according to Sheila Bazzaz, MD.

Recently, a ranking of U.S. business schools was published by Forbes magazine. The top school, according to this ranking, was the Tuck School of Business at Dartmouth College, Hanover, NH. The criterion used to determine the "best" school was a remarkable one: starting salary of recent graduates. This struck me as an interesting measure of the quality of an education.

Lisbon, Portugal—A deep lamellar keratoplasty (DLKP) procedure that exposes Descemet's membrane seems safe and effective to correct keratoconus, according to Mohamed Alaa El-Danasoury, MD, who reported his group's 1-year experience with the procedure.

Chicago—Results of the 2005 International Society of Refractive Surgery (ISRS)/American Academy of Ophthalmology (AAO) survey highlight some interesting trends in refractive surgery across the United States, said Richard J. Duffey, MD, at the refractive subspecialty meeting sponsored by the ISRS/AAO.

Lisbon, Portugal—The use of fibrin glue seems to be effective and safe in total anterior lamellar keratoplasty (TALK), a procedure that completely exposes Descemet's membrane within the area of host corneal trephination. Thomas John, MD, explained the procedure, which involves the transplantation of donor cornea without Descemet's membrane and endothelium, at the European Society of Cataract and Refractive Surgeons annual meeting.

Washington, DC—Physicians nationwide, including ophthalmologists, will endure a 4.4% reduction in reimbursements effective Jan. 1 in light of the Centers for Medicare and Medicaid Services' (CMS) newly released 2006 Physician Fee Schedule.

Washington, DC—Two years after a Cleveland ophthalmologist began lobbying Congress to regulate cosmetic contact lenses as medical devices, the bill is on its way to the president's desk for a signature.

With surface ablation procedures becoming more common, surgeons have developed a combination therapy management approach including a fluoroquinolone antibiotic, a nonster-oidal anti-inflammatory drug (NSAID), and a steroid to prevent infection and reduce pain.

Los Angeles—Results from the Xibrom First Experience (XFE) trial show that the new twice-a-day nonsteroidal anti-inflammatory drug (NSAID) is being well received by cataract surgeons and their patients alike, said David F. Chang, MD.

Chicago—After topical administration, moxifloxacin 0.5% (Vigamox, Alcon Laboratories) penetrates better into the cornea than gatifloxacin 0.3% (Zymar, Allergan) to achieve significantly higher levels in the epithelium and stroma, reported Terry Kim, MD, at the annual meeting of the Ocular Microbiology and Immunology Group.

Chicago—Nepafenac ophthalmic suspension 0.1% (Nevanac, Alcon Laboratories) is a significant advance in the treatment of pain and inflammation associated with cataract surgery. The nonsteroidal anti-inflammatory prodrug offers well-tolerated, effective, target-specific therapy that may enhance patient compliance and quality of vision outcomes, said Robert P. Lehmann, MD, FACS, at the annual meeting of the American Academy of Ophthalmology.

Chicago-A number of advances have been made in the ability to diagnose and manage optic nerve sheath meningiomas. Neil R. Miller, MD, described how best to handle these tumors during the William F. Hoyt Lecture at the American Academy of Ophthalmology annual meeting.

With cataract and refractive procedures, ocular comfort and inflammation management are highly relevant to the patient's impression of a successful procedure. Add to that an expectation that an increase in visual acuity will follow closely on the heels of surgery, and the standards are set very high.

Glaucoma presents a significant challenge for researchers seeking to adapt what is learned about genetics in labs to strategies that can be used in patient care.

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Montr?al—Oral moxifloxacin (Avelox, Bayer) can penetrate into the vitreous at a level that can kill most common pathogens in the eye. This drug, a fluoroquinolone, may play a role in the treatment or prevention of endophthalmitis.