Theorharis Theorharides, MD

Secretaria de Estado de Saúde do Distrito Federal-Adolescentro



Dr. Theorharides, professor of pharmacology and internal medicine and biochemistry, Tufts Unversity School of Medicine and New England Medical Center, Boston.


Allergy agent more potent in inhibition of IL-6, tryptase

Boston-Ophthalmic solutions of azelastine HCl (Optivar, Asta Medica/Muro Pharmaceutical Inc., Tewksbury, MA) and olopatadine HCl (Patanol, Alcon Laboratories, Fort Worth, TX) both effectively inhibit the activation of normal cultured human mast cells and the release of interleukin-6 (IL-6), tryptase, and histamine. However, azelastine seemed to be substantially more potent for treating ocular allergy when the two drugs were compared in an in vitro study.