
- Ophthalmology Times: September 1, 2020
- Volume 45
- Issue 14
Are posterior corneal curvature changes culprit in hyperopic shifts?
Changes after DMEK, UT-DSAEK may be factors in reduced total corneal refractive power
Total corneal refractive power has always been a consideration, but not much has been known until now about why it changes in response to Descemet’s membrane endothelial keratoplasty (DMET) and ultrathin Descemet’s endothelial keratoplasty (UT-DSAEK).
The randomly selected, controlled Descemet Endothelial Thickness Comparison (DETECT) Trial identified decreases in the total corneal refractive power initially and then increases at 6 and 12 months postoperatively.
Related:
The changes seemed to reflect steepening in the posterior corneal curvature; despite that increase, the total corneal refractive power decreased from baseline to 12 months.
This may have implications for IOLs during cataract surgery, according to Elizabeth Shen, MD, of the Oregon Health and Science University in Portland.
To collect data on how the corneal refractive power responds to these corneal procedures, 50 eyes of 38 patients were randomly selected to undergo either DMEK or UT-DSAEK to address isolated endothelial dysfunction.
Tomography data were collected at baseline and postoperatively at 3, 6, 12, and 24 months.
The primary outcomes of the DETECT Trial were the total corneal refractive power at the 3-mm zone, anterior and posterior simulated keratometry, and the predicted refractive outcome using the Holladay 1 formula compared with the postoperative manifest refraction.
Investigators also evaluated patients who underwent endothelial keratoplasty and
Related:
Findings
The total corneal refractive power decreased in response to both DMEK and UT-DSAEK at 3 months postoperatively and then increased at 6 and 12 months.
Despite the tendency to increase, the parameter overall decreased significantly (P < .001 for all comparisons at each time point) with both procedures from baseline to 24 months, Shen reported.
The mean change in the total cornea refractive power after DMEK from baseline to 12 months was a reduction of + 0.8 dD and for UT-DSAEK a reduction of + 0.69 D. The difference did not reach significance.
This raised the question of why a decrease in the total corneal refractive power occurs. When investigators evaluated the anterior corneal curvature in relation to the changes from baseline out to 12 months, they found that the change with DMEK was + 0.23 D and with UT-DSAEK + 0.11, not significant from baseline.
Related:
The mean change in the posterior corneal curvature at 12 months with DMEK was – 0.42 D and with UT-DSAEK – 0.54 D, which also was not significant.
Shen noted that the decrease represents a steepening of the posterior corneal curvature. At each time point evaluated, there was a significant change compared with baseline.
The investigators also looked at the refractive outcomes after triple procedures. The analysis showed a mean refractive shift toward hyperopia of + 0.6 D with DMEK and with UT-DSAEK + 0.4 D.
Most of the outcomes had a hyperopic shift from the so-called triple procedures, but a myopic shift also occurred. No difference was seen in the refractive outcomes between DMEK and UT-DSAEK.
Related:
A key takeaway point is that the total corneal refractive power in DMEK and UT-DSAEK decreased at first and then increased at 6 and 12 months.
Despite the increase, the total corneal refractive power decreased from baseline to 12 months.
This loss of corneal power likely results from changes in the posterior curvature, which steepened over time and contributed to hyperopic shifts after endothelial keratoplasty.
The results did not differ between DMEK and UT-DSAEK.
--
Elizabeth Shen, MD
e: [email protected]
Shen has no financial interest in this subject matter.
Articles in this issue
almost 5 years ago
Improve patient comfort with intravitreal injectionsabout 5 years ago
Stem cells for dry AMD with GA show promise in early studyabout 5 years ago
Ophthalmology taking the treatment conversation onlineabout 5 years ago
Astigmatism management software proving to be accurate, preciseabout 5 years ago
Examining ocular allergy, quality of lifeabout 5 years ago
Improving surgical safety, efficiency, and outcomes for patientsabout 5 years ago
FAF shedding light on patterns related to disease chronicity in CSCabout 5 years ago
IOL offering treatment options for ophthalmologistsabout 5 years ago
Unproductive worry: Conquering fear during a pandemicNewsletter
Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.