Article

New artificial cornea research could promise increased availability

In an effort to make corneal transplants more available, researchers have designed an artificial cornea made from a water-filled polymer that resembles the eye's natural cornea.

 

 

Instead of using hard plastic similar to previously designed corneal implants, Curtis Frank, chemical engineer, Stanford University, and former graduate student David Myung have created an artificial cornea based on a soft hyrdogel.

The material is mechanically robust, despite consisting of 80% water. The high water content is crucial for allowing glucose and nutrients to diffuse through the cornea and encourage growth of epithelial cells on the implant's surface, according to researchers.

To make cells stick to the cornea, which they do not do normally, the researchers devised a way of tethering collagen to the artificial corneas surface. They also can create patterns of microscopic pores around the edges of the implant so that when the cornea is implanted in the patient's eye, cells will migrate through the pores, anchor the cornea, and help integrate the material with the native tissue.

Currently, the researchers have shown that the diffusion of glucose across the material is equal to that of the human cornea and preliminary studies in rabbits show that the growth of epithelial cells is supported by the implants. Studies in human patients are several years away, according to researchers.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times) ASCRS 2025: Mark Lobanoff, MD, on making the move to office-based surgery
Barsha Lal, PhD, discusses the way low dose atropine affects accommodative amplitude and dynamics at the 2025 ARVO meeting
(Image credit: Ophthalmology Times) NeuroOp Guru: When eye findings should prompt neuroimaging in suspected neuro-Behcet disease
At the Association for Research in Vision and Ophthalmology (ARVO) meeting, Katherine Talcott, MD, a retina specialist at Cleveland Clinic, shared her findings on EYP-1901 (EyePoint Pharmaceuticals) in the phase 2 DAVIO study.
Dr. Jogin Desai, founder of Eyestem Research, discusses his research at the Association for Research in Vision and Ophthalmology.
(Image credit: Ophthalmology Times) ASCRS 2025: Michael Rivers, MD, shares his takeaways as a panelist at the inaugural SightLine event
(Image credit: Ophthalmology Times) ASCRS 2025: Karl Stonecipher, MD, on LASIK outcomes using an aspheric excimer laser for high myopia
John Tan talks about an emergency triage framework for retinal artery occlusion at the 2025 Association for Research in Vision and Ophthalmology (ARVO) meeting.
Dr Robert Maloney at the 2025 Controversies in Modern Eye Care meeting
Wendy Lee, MD, MS, at Controversies in Modern Eye Care 2025.
© 2025 MJH Life Sciences

All rights reserved.