News

Video

ASRS Live: 2-year data on the PHOTON study of 8 milligrams of aflibercept for diabetic macular edema (DME)

At the 2023 ASRS meeting in Seattle, Washington, Diana Do, MD joined our team to discuss the 2-year data on the PHOTON study, which involved 8 milligrams of aflibercept for diabetic macular edema.

At the 2023 ASRS meeting in Seattle, Washington, Diana Do, MD joined our team to discuss the 2-year data on the PHOTON study, which involved 8 milligrams of aflibercept for diabetic macular edema.

Video Transcript

Editor's note - This transcript has been edited for clarity.

Diana Do, MD:

Hi, I'm Dr Diana Do, professor of ophthalmology and vice chair of clinical affairs at the Byers Eye Institute at Stanford University. Today, I had the pleasure of delivering the 2-year data on the PHOTON study, which involved 8 milligrams of aflibercept for diabetic macular edema.

The key take home points are that 8 milligrams of aflibercept dosed every 12 weeks or every 16 Weeks was non -nferior to 2 milligrams of aflibercept given every 8 weeks, and these benefits were sustained through 2 years of follow up. In addition, it's remarkable that those eyes randomized to the 8 milligram dosing group were able to maintain dosing intervals of 12 weeks and 16 weeks for the vast majority of patients in the study. In fact, 89 percent of 8 milligram-treated eyes maintained 12 weeks or longer dosing intervals through 2 years. And at the last interval of dosing. Approximately 27 percent of subjects are able to be dosed at 24 weeks. In terms of safety, 8 milligrams of aflibercept had very low rates of intraocular inflammation, and the safety was comparable to that of 2 milligrams of aflibercept. In summary, 8 milligrams of aflibercept provided improved visual acuity outcomes and reductions in retinal thickness that were sustained through 2 years while decreasing the burden of frequent injections.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times Europe) Anat Loewenstein, MD, shares insights on the real-world results of remote retinal imaging
(Image credit: Ophthalmology Times) Two-wavelength autofluorescence for macular xanthophyll carotenoids with Christine Curcio, PhD
(Image credit: Ophthalmology Times) FLIO and the brain: Making the invisible visible with Robert Sergott, MD
(Image credit: Ophthalmology Times) Structure-function correlates using high-res OCT images with Karl Csaky, MD, PhD
(Image credit: Ophthalmology Times) SriniVas Sadda, MD, on high-res OCT of atrophic and precursor lesions in AMD
(Image credit: Ophthalmology Times) Christine Curcio, PhD, shares histology update supporting review software and revised nomenclature for <3 μm OCT
Steven R. Sarkisian, Jr., MD, ABO, speaks about glaucoma at the 2025 ASCRS annual meeting
© 2025 MJH Life Sciences

All rights reserved.