The Vanderbilt University Medical Center study contradicts earlier studies from East Asia that showed the small dose of atropine is effective in slowing progression of myopia.
Vanderbilt University Medical Center (VUMC) and 11 other hospitals and practices across the United States have teamed up to conduct a study that demonstrates the use of low-dose atropine eyedrops, commonly used in a higher dose to treat lazy eye, was no better than a placebo at slowing myopia progression and elongation of the eye among children treated for two years.
According to a VUMC news release, the first randomly assigned controlled trial of its kind aimed at identifying an effective way to manage myopia was published last week in JAMA Ophthalmology.1 It was conducted by the Pediatric Eye Disease Investigator Group and funded by the National Eye Institute (NEI).
“We found, interestingly, and honestly shockingly, that there was no difference in the use of 0.01% atropine and placebo in treating these children who ranged in age from 5 to 12,” said Lori Ann Kehler, OD, an associate professor of Ophthalmology and Visual Sciences, chief of the Optometry Service and the Vanderbilt site principal investigator for the study.
Of the 187 trial participants, Kehler noted that 21 were from VUMC.
According to VUMC, the onset of myopia usually occurs between the ages of 7 and 16 when developing eyes can start growing too long axially (from front to back). Instead of focusing images on the retina – the light-sensitive tissue in the back of the eye – images of distant objects are focused at a point in front of the retina which causes people to have poor distance vision while their near vision remains unchanged.
Moreover, the VUMC pointed out the condition results in the need for eyeglasses to improve distance vision, and it can also result in medical complications and serious uncorrectable vision loss later in life, like retinal detachments or myopic macular degeneration.
The VUMC study, according to the news release, contradicts earlier studies from East Asia that showed the small dose of atropine is effective in slowing progression of myopia.
VUMC noted in the news release that six years ago, the FDA had not approved atropine for this use, there was sufficient evidence for prescribing the low dose for myopia. Ophthalmologists across the country, including at VUMC, began to offer the prescription to young patients with myopia.
“That was a really exciting finding at the time because we had had no treatment options for many years,” Kehler said in the news release. The prescription of atropine for treating myopia is not covered by most insurance plans.
Kehler also noted in the news release that incidence of myopia is on the rise worldwide.
“By 2030 it’s predicted that 39 million people in the U.S. will have myopia,’ she said in the news release. “By 2050 that number is expected to increase to more than 44 million people in the U.S. and to 50% of the global population. Once it’s detected in children, it tends to get worse every year,” she said. “Investigators all over the world have tried strategies to intervene, to either stop or slow the worsening of myopia.”
Kehler said it is not known why the incidence of myopia is increasing, but she pointed out in the news release that there are several theories.1
“Some believe it’s the increase in the use of screens and screen time, but myopia was increasing even before screens were part of children’s lives,’ she said in the VUMC news release. ”Others think it has to do with industrialization. We were an agricultural society. We were outside more. We weren’t reading. We weren’t looking up close all day. Really, the prevailing thought is whether we’re at a screen or looking at a math book or reading most of the day, we think the lack of sunlight and sustained near effort is what’s causing the increase of myopia.”
Kehler said in the release the percentage of children with myopia using the atropine drop at VUMC is low and she estimates fewer than 5% of children with myopia are using the drops nationally.
Going forward, eye specialists should have a frank discussion with parents of children with myopia about the conflicting data between the Asian studies and the new U.S. study.
Michael X. Repka, MD, professor of Ophthalmology at Johns Hopkins University, in a news release from the NEI, explained the absence of a treatment benefit in the U.S.-based study, compared to East Asian studies, may reflect racial differences in atropine response.
“The study enrolled fewer Asian children, whose myopia progresses more quickly, and included Black children, whose myopia progresses less quickly compared with other races,” Repka said in the release.
Kehler also explained that the current studies have all demonstrated the safety and efficiency of the drops, so children aren’t being put at risk should physicians continue to prescribe the 0.01%.
“But we are telling them there is a difference in these studies and it might have to do with your genetics; it might be that it’s more effective in children from Asia than in the U.S. population,” she said in the news release.
Additional research is needed, according to Kehler, and the next step is likely to study a higher dose of atropine to see if children in the U.S. experience a benefit.
A study out of Hong Kong – the LAMP study – found that 0.05% might be more effective.
Kehler said other groups are studying the use of red-light therapy to slow the progression of myopia, and there are also new eyeglass lenses that have been developed to slow the progression of myopia, but they are not yet available in the U.S.
“It’s much harder to get drops in very young children,” Kehler concluded in the VUMC news release. “But if we had a spectacle option, that would open the door to treating our younger patients.”
Myopia usually stabilizes in about half of children around 16 years of age and among an increasingly larger percentage as they get older. By their early 20s, about 10% of individuals with myopia will continue to grow more nearsighted, and by age 24 that percentage is 4%.