Article

The use of intravitreal ranibizumab safe for wet AMD

An extension study shows that long-term ranibizumab therapy is safe and well-tolerated.

Key Points

Dr. Jumper, a private practitioner in San Francisco, is a principal investigator for several trials of ranibizumab. Although the small number of patients in the study limits its statistical power, he said, the rate of thromboembolic events was consistent with that of other studies of ranibizumab.

Enrollment in the extension study included patients who had taken part in the first clinical trials of ranibizumab, dating back to about the year 2000, in which investigators were trying to determine the best-tolerated and most-effective dose. Because the drug demonstrated effectiveness during those early trials, investigators invited the patients to continue in an extension study to gather long-term data, Dr. Jumper said. Mean duration of therapy for the 67 treated patients in the extension study was 3.8 years (range, 0.9 to 5 years).

The primary outcome measurement was the discovery of any major adverse events related to long-term treatment. "None were discovered," Dr. Jumper said. "The ocular adverse events were similar to those that we've seen in the other big ranibizumab trials, and the systemic adverse events were in line with other published information on the drug."

The rate for development of the first arterial thromboembolic event was 4.1% per year, comparable to the rates observed in other studies, he added.

"I counsel my patients that [ranibizumab] therapy is a lifelong treatment; how many injections and at what interval I won't know, but you have to think in terms of this being a treatment you get very long-term," Dr. Jumper said. "However, it doesn't seem that long-term therapy is leading to worse problems than we see in the first 2 years," he said.

Nevertheless, he said that ongoing studies with more participants might reveal more about possible systemic adverse events.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times)  ASCRS 2025: Joaquin De Rojas, MD, leverages machine learning model to predict arcuate outcomes
(Image credit: Ophthalmology Times) ASCRS 2025: AnnMarie Hipsley, DPT, PhD, presents VESA for biomechanical simulation of presbyopia progression
Shehzad Batliwala, DO, aka Dr. Shehz, discussed humanitarian ophthalmology and performing refractive surgery in low-resource, high-risk areas at the ASCRS Foundation Symposium.
(Image credit: Ophthalmology Times) ASCRS 2025: Advancing vitreous care with Inder Paul Singh, MD
(Image credit: Ophthalmology Times) The Residency Report: Study provides new insights into USH2A target end points
Lisa Nijm, MD, says preoperative osmolarity testing can manage patient expectations and improve surgical results at the 2025 ASCRS annual meeting
At the 2025 ASCRS Annual Meeting, Weijie Violet Lin, MD, ABO, shares highlights from a 5-year review of cross-linking complications
Maanasa Indaram, MD, is the medical director of the pediatric ophthalmology and adult strabismus division at University of California San Francisco, and spoke about corneal crosslinking (CXL) at the 2025 ASCRS annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Taylor Strange, DO, assesses early visual outcomes with femto-created arcuate incisions in premium IOL cases
(Image credit: Ophthalmology Times) ASCRS 2025: Neda Shamie, MD, shares her early clinical experience with the Unity VCS system
© 2025 MJH Life Sciences

All rights reserved.