Article

Preclinical and early clinical experience encouraging for novel ocular sealant

A polyethylene glycol-based ocular sealant is being developed as a synthetic bandage for clear corneal incisions to prevent wound gape, hypotony, and intraocular contamination. Preclinical and early clinical study results support its efficacy and safety.

Key Points

The PEG-based sealant is being developed as a synthetic ocular bandage that will persist long enough to allow incision healing and thereby provide a barrier against intraocular microbial entry. The product is colorless and transparent so as not to impair vision. Additionally, it is non-toxic, and its use has not been associated with pain, inflammation, or induction of astigmatism.

The PEG-based sealant is applied as a liquid and forms a soft hydrogel on the eye within 25 seconds. The branched spider shape of the polymer promotes adhesiveness and increases mechanical intercalation that promotes stickiness to close the clear corneal cataract incisions safely.

Initial evaluations performed in rabbit eyes demonstrated that the PEG-based sealant was non-cytotoxic, non-sensitizing, non-irritating, non-toxic to intraocular tissues, and not associated with acute systemic toxicity.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times Europe) Anat Loewenstein, MD, shares insights on the real-world results of remote retinal imaging
(Image credit: Ophthalmology Times) Two-wavelength autofluorescence for macular xanthophyll carotenoids with Christine Curcio, PhD
(Image credit: Ophthalmology Times) FLIO and the brain: Making the invisible visible with Robert Sergott, MD
(Image credit: Ophthalmology Times) Structure-function correlates using high-res OCT images with Karl Csaky, MD, PhD
(Image credit: Ophthalmology Times) SriniVas Sadda, MD, on high-res OCT of atrophic and precursor lesions in AMD
(Image credit: Ophthalmology Times) Christine Curcio, PhD, shares histology update supporting review software and revised nomenclature for <3 μm OCT
1 expert is featured in this series.
1 expert is featured in this series.
1 expert is featured in this series.
1 expert is featured in this series.
© 2025 MJH Life Sciences

All rights reserved.