Article

New hope in sight for AMD

A special session on age-related macular degeneration (AMD) sponsored by Novartis Ophthalmics was held at the W New Orleans Hotel to spotlight the direction research is taking with the disease.

New Orleans-A special session on age-related macular degeneration (AMD) sponsored by Novartis Ophthalmics was held at the W New Orleans Hotel to spotlight the direction research is taking with the disease.

David Saperstein, MD, of Seattle, presented an overview of AMD and why it is becoming even more of a public health burden.

"As the population ages, the problem of AMD grows and the risk of developing the disease increases. Three million people will have advanced disease by 2020," he said. The goal today, he emphasized, is to identify the patients who are at risk of developing AMD and treat them early to obtain better visual results, but the ultimate goal is to prevent the disease altogether.

Peter Kaiser, MD, of Cleveland, highlighted the newest treatment strategies and explained the results of the most recent clinical trials.

"As of now, the FDA has approved only two treatments, laser photocoagulation and photodynamic therapy with verteporfin. Both of these reduce vision loss, but do not improve visual acuity," he said. "The exciting area now is pharmacotherapy that are nearing approval, namely, the anti-VEGF inhibitors (Macugen [Eyetech] and Lucentis [Genentech]), a steroid analog (Retaane, [Alcon]), steroids, and combination therapies."

Johanna Seddon, MD, of Boston, talked about the risk factors for AMD, such as diet and smoking among others, that are similar to the risk factors for cardiovascular disease and cancer, and explored the value of biomarkers in predicting patient susceptibility to AMD. An important finding thus far is the research indicating that C-reactive protein (CRP) is a systemic inflammatory marker associated with risk for developing cardiovascular disease.

"CRP has been shown to be an independent indicator of risk for cardiovascular and peripheral arterial diseases," Dr. Seddon said. "CRP is growing in importance in terms of what other diseases it is associated with."

Dr. Seddon's most recent work suggested that an elevated CRP level is an independent risk factor for AMD and suggests that inflammation is a component in the development of AMD.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times) The Residency Report: Study provides new insights into USH2A target end points
Lisa Nijm, MD, says preoperative osmolarity testing can manage patient expectations and improve surgical results at the 2025 ASCRS annual meeting
At the 2025 ASCRS Annual Meeting, Weijie Violet Lin, MD, ABO, shares highlights from a 5-year review of cross-linking complications
Maanasa Indaram, MD, is the medical director of the pediatric ophthalmology and adult strabismus division at University of California San Francisco, and spoke about corneal crosslinking (CXL) at the 2025 ASCRS annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Taylor Strange, DO, assesses early visual outcomes with femto-created arcuate incisions in premium IOL cases
(Image credit: Ophthalmology Times) ASCRS 2025: Neda Shamie, MD, shares her early clinical experience with the Unity VCS system
Patricia Buehler, MD, MPH, founder and CEO of Osheru, talks about the Ziplyft device for noninvasive blepharoplasty at the 2025 American Society of Cataract and Refractive Surgeons (ASCRS) annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Bonnie An Henderson, MD, on leveraging artificial intelligence in cataract refractive surgery
(Image credit: Ophthalmology Times) ASCRS 2025: Gregory Moloney, FRANZO, FRCSC, on rotational stability
Sheng Lim, MD, FRCOphth, discusses the CONCEPT study, which compared standalone cataract surgery to cataract surgery with ECP, at the 2025 ASCRS Annual Meeting.
© 2025 MJH Life Sciences

All rights reserved.