The lens regrowth hypothesis
In March 2016, the lens regrowth hypothesis was transformed into a distinct clinical possibility. Investigators from China and the United States reported their findings in Nature detailing a series of experiments in animals and children up to 2 years of age
Stem cells and regenerative medicine are hot topics in biological research, medicine, and ophthalmology. Although scientific and lay press frequently discuss the promise of these therapies for optic nerve and retinal disorders as being just around the corner, real progress has been slow to achieve and often beset by unrealistic expectations and poor results.1
Related:
While the introduction of a polymer IOL was revolutionary with many millions implanted annually around the world, the chance to replace the human crystalline lens with a functioning, biologic product has been the dream of many ophthalmologists. Among many was Charles Kelman, MD, ever a visionary, when he obtained a patent for the removal of cataractous lens protein and refilling the capsular bag with purified soluble or partially fibrillar collagen.2
Related:
This biological lens was expected to be engineered with appropriate optical clarity and more normal function including accommodation.
More recently, the idea of replacing the lens protein of an infantile cataract by having the body simply regenerate a crystalline lens in place has been discussed. Following lensectomy in infant eyes, pediatric ophthalmologists have noted remarkably clear lens protein expanding the space between the anterior and posterior capsule circular remnants, rather than seeing the capsule leaflets fuse together.
Internal server error