Article

Hyperspectral imaging measures retinal oxygen levels

Measuring the oxygen level of the retinal tissues may allow detection of retinal changes in patients with diabetes before structural changes in the capillaries occur, said Amani Fawzi, MD, Doheny Eye Institute, University of Southern California, Los Angeles.

Measuring the oxygen level of the retinal tissues may allow detection of retinal changes in patients with diabetes before structural changes in the capillaries occur, said Amani Fawzi, MD, Doheny Eye Institute, University of Southern California, Los Angeles.

Dr. Fawzi and colleagues are developing a hyperspectral oxygen camera to obtain color images of the retina that detail the level of oxygen saturation of the tissues. One snapshot captures spatial and spectral data and the oximetry information can be extracted and analyzed.

Investigators tested the accuracy of the instrument based on previous knowledge that there can be about a 30% difference in oximetry between the arteries and veins in the retina. Images confirmed the difference between the structures, with the arteries having about 90% oxygen saturation and the veins about 70% saturation, Dr. Fawzi said.

She showed images of the macula in patients with branch and central vein occlusions and diabetic retinopathy that showed capillary damage and zones of foveal avascularity. She also demonstrated the effect of treatment with bevacizumab (Avastin, Genentech) in a patient with central vein occlusion and that the oximetry increased after treatment, which explains the immediate increase in vision after injection.

"This technology is a robust means to image retinal oximetry," Dr. Fawzi said. "It is rapid and noninvasive. Low oxygen levels correlated with ischemia/nonperfusion in retinal vasculature disease. The hope is that imaging can detect changes before structural damage occurs and result in treatment algorithms before structural damage occurs."

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
(Image credit: Ophthalmology Times) ASCRS 2025: Mark Lobanoff, MD, on making the move to office-based surgery
Barsha Lal, PhD, discusses the way low dose atropine affects accommodative amplitude and dynamics at the 2025 ARVO meeting
(Image credit: Ophthalmology Times) NeuroOp Guru: When eye findings should prompt neuroimaging in suspected neuro-Behcet disease
At the Association for Research in Vision and Ophthalmology (ARVO) meeting, Katherine Talcott, MD, a retina specialist at Cleveland Clinic, shared her findings on EYP-1901 (EyePoint Pharmaceuticals) in the phase 2 DAVIO study.
Dr. Jogin Desai, founder of Eyestem Research, discusses his research at the Association for Research in Vision and Ophthalmology.
(Image credit: Ophthalmology Times) ASCRS 2025: Michael Rivers, MD, shares his takeaways as a panelist at the inaugural SightLine event
(Image credit: Ophthalmology Times) ASCRS 2025: Karl Stonecipher, MD, on LASIK outcomes using an aspheric excimer laser for high myopia
John Tan talks about an emergency triage framework for retinal artery occlusion at the 2025 Association for Research in Vision and Ophthalmology (ARVO) meeting.
Dr Robert Maloney at the 2025 Controversies in Modern Eye Care meeting
Wendy Lee, MD, MS, at Controversies in Modern Eye Care 2025.
© 2025 MJH Life Sciences

All rights reserved.