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Chicago-In the late 1980s, ophthalmologists were challenged by Eddy and Billings to prove that IOP was an essential element in the management of primary open-angle glaucoma (POAG). Recent results from a number of National Eye Institute (NEI)-sponsored randomized controlled trials confirm that IOP reduction is effective in slowing both disease development and its progression. The results of those studies, however, have raised new issues in glaucoma management.