Article

Forms of amblyopia can be identified by varying patterns of visual deficits

Author(s):

San Francisco-There are distinct forms of amblyopia characterized by varying patterns of visual deficits. Both blurred imagery and the loss of binocular function can cause amblyopia and determine the pattern of visual deficit, said Suzanne P. McKee, PhD, who reported on the results of an NEI-sponsored study analyzing a comprehensive set of visual function data collected in a large group of patients with amblyopia.

San Francisco-There are distinct forms of amblyopia characterized by varying patterns of visual deficits. Both blurred imagery and the loss of binocular function can cause amblyopia and determine the pattern of visual deficit, said Suzanne P. McKee, PhD, who reported on the results of an NEI-sponsored study analyzing a comprehensive set of visual function data collected in a large group of patients with amblyopia.

"The finding that loss of binocular function plays a causal role in the development of amblyopia came as a surprise to us," said Dr. McKee, senior scientist, Smith-Kettlewell Eye Research Institute, San Francisco. "This research suggests that rather than trying to cure amblyopia, there may be two things we can do to prevent it. First, we need to correct refractive error early in children with anisometropia and thereby minimize image blurring when acuity is developing. Secondly, and more difficult, we need to get the eyes straight enough to preserve binocularity in the central visual field."

The subjects were divided into 11 clinically defined categories: strabismics, inconstant strabismics, former strabismics, anisometropes, deprivationals, inconstant strabismic anisometropes, other abnormals, strabismic anisometropes, eccentric fixators, refractives, and normals. The number of persons in each group ranged from 18 to 101.

Using factor analysis to represent the vast database, the researchers first found that two independent factors-an acuity factor and a contrast sensitivity factor-accounted for about 80% of the variance in visual function of the abnormals. Based on those findings, the data for each of the clinical categories were represented in a two-factor measurement space divided into four quadrants using a horizontal acuity axis and a vertical contrast sensitivity axis. The factor space, and the location of the various clinical categories, is shown in Figure 1 with the division between binocular and non-binocular groups cutting diagonally across this space.

From that method of depiction, it was clear that different patient categories exhibited distinctive patterns of visual loss. Notably the anisometropes and deprivationals were adjacent in this space due to their poor contrast sensitivity and moderate loss in acuity. Intriguingly, all of the pure strabismic groups had supernormal monocular contrast sensitivity. Despite their superior contrast sensitivity, the acuity of the strabismics was no better than the acuity of anisometropes.

Newsletter

Don’t miss out—get Ophthalmology Times updates on the latest clinical advancements and expert interviews, straight to your inbox.

Related Videos
Lisa Nijm, MD, says preoperative osmolarity testing can manage patient expectations and improve surgical results at the 2025 ASCRS annual meeting
At the 2025 ASCRS Annual Meeting, Weijie Violet Lin, MD, ABO, shares highlights from a 5-year review of cross-linking complications
Maanasa Indaram, MD, is the medical director of the pediatric ophthalmology and adult strabismus division at University of California San Francisco, and spoke about corneal crosslinking (CXL) at the 2025 ASCRS annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Taylor Strange, DO, assesses early visual outcomes with femto-created arcuate incisions in premium IOL cases
(Image credit: Ophthalmology Times) ASCRS 2025: Neda Shamie, MD, shares her early clinical experience with the Unity VCS system
Patricia Buehler, MD, MPH, founder and CEO of Osheru, talks about the Ziplyft device for noninvasive blepharoplasty at the 2025 American Society of Cataract and Refractive Surgeons (ASCRS) annual meeting
(Image credit: Ophthalmology Times) ASCRS 2025: Bonnie An Henderson, MD, on leveraging artificial intelligence in cataract refractive surgery
(Image credit: Ophthalmology Times) ASCRS 2025: Gregory Moloney, FRANZO, FRCSC, on rotational stability
Sheng Lim, MD, FRCOphth, discusses the CONCEPT study, which compared standalone cataract surgery to cataract surgery with ECP, at the 2025 ASCRS Annual Meeting.
(Image credit: Ophthalmology Times) ASCRS 2025: Steven J. Dell, MD, reports 24-month outcomes for shape-changing IOL
© 2025 MJH Life Sciences

All rights reserved.