• COVID-19
  • Biosimilars
  • Cataract Therapeutics
  • DME
  • Gene Therapy
  • Workplace
  • Ptosis
  • Optic Relief
  • Imaging
  • Geographic Atrophy
  • AMD
  • Presbyopia
  • Ocular Surface Disease
  • Practice Management
  • Pediatrics
  • Surgery
  • Therapeutics
  • Optometry
  • Retina
  • Cataract
  • Pharmacy
  • IOL
  • Dry Eye
  • Understanding Antibiotic Resistance
  • Refractive
  • Cornea
  • Glaucoma
  • OCT
  • Ocular Allergy
  • Clinical Diagnosis
  • Technology

Better outcomes possible for keratoconus patents


London-The visual outcomes of patients with keratoconus were improved when using a femtosecond laser (IntraLase, Advanced Medical Optics Inc.) to create the channels for implantation of intrastromal corneal implants (Intacs, Addition Technology Inc.), according to Sheraz Daya, MD, FACS.

In addition, the visual acuity levels were sustained over time in these patients compared with those who underwent a mechanical procedure for channel creation and experienced a substantial decrease in visual acuity over time, said Dr. Daya. He is director and consultant, Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, East Grinstead, and medical director, Centre for Sight, London and East Grinstead, England.

"[The corneal implants] have traditionally been implanted using mechanical means," Dr. Daya said. "An issue associated with this procedure is the accuracy of the ring depth, which can result in extrusions and infections. With experience this improves.

Dr. Daya has changed the nomogram from the manufacturer's recommendation based on his mechanical outcomes, he explained. "I decreased the size of the inner ring to 6.3 mm [from 6.6 mm] and outer channel to 7.1 mm [from 7.5 mm], making the channel diameter also smaller to 0.4 mm. The rationale for this change is that the smaller outer diameter forces more flattening as the rings, which are larger in diameter than the channels, exert vector forces on the cornea outwards," he said.

Dr. Daya and his colleagues have used both the mechanical method and the femtosecond method. The incision axis, he explained, is based on the steep axis. The asymmetrical rings were used only in pellucid-like keratoconus, which requires a horizontal incision.

He described a patient who had a mean keratometry value of 52.3 D. Two months after corneal insert implantation that value decreased to a mean of about 42.5 D.

When the investigators compared their outcomes from the two groups, there were more patients in the laser group. There were 32 eyes of 30 patients in the laser group and 17 eyes of 16 patients in the mechanical group.

"We abandoned doing this surgery with the mechanical method because the outcomes were very poor," he said. Following installation of femtosecond laser, Dr. Daya recommenced corneal insert implantation.

"The mean keratometry value was slightly higher with the group that underwent the mechanical procedure," he said. "We previously had done the surgery on all patients with a clear cornea and very high keratometry values. Since then we have decided that this is a bad idea. We no longer do the procedure on any patient with greater than 57 D of keratometry."

The only difference between the two methods, he pointed out, is that with the mechanical procedure the channels can be deeper than 400 μm, which is the limit with the laser method. Regarding the changes in keratometry, the patients who underwent the conventional procedure and the laser procedure both had a gradual decline in keratometry values, which was sustained over time. The spherical equivalent also decreased in both groups, but the degree of decrease was greater in the laser group.

Better-corrected vision

The laser group had a better best-corrected visual outcome compared with the conventional group.

"The patients in the mechanical group hovered around the 20/50 visual acuity level, while the patients in the [laser] group had an average visual acuity of 20/40 to 20/30," Dr. Daya reported.

In the mechanical group, 38% of patients had 20/40 or better visual acuity 3 months after the procedure; however, only 8% at 6 months sustained that level of visual acuity. In the laser group, 29% of patients had 20/40 acuity or better 3 months after the procedure, and this increased to 67% at 6 months, he said.

One perforation and one infection occurred in the conventional group. Three infections occurred in the laser group.

Related Videos
EyeCon Co-chair Oluwatosin U. Smith, MD: Passion for Research and Education Drives Her Commitment to Ophthalmology
Dr. SriniVas Sadda Discusses Vision for ARVO as New President: Collaboration, Funding Challenges, and Impact of Annual Meetings
Highlights from the 18th Annual Controversies in Modern Eye Care Symposium: Arjan Hura, MD, on Refractive Surgery, Retina Care, and Record Attendance
ASCRS 2024: ViaLase Updates on Nonincisional Glaucoma Treatment Targeting Trabecular Meshwork
Dr. Neda Nikpoor Shares Practical Techniques to Combat Unconscious Gender Bias and Promote Gender Equality in Ophthalmology
ASCRS 2024: George O. Waring, MD, shares early clinical performance of bilateral Odyssey implantation
ASCRS 2024: Deborah Gess Ristvedt, DO, discusses third-generation trabecular micro-bypass
Arjan Hura, MD, highlights the clinical and surgical updates at CIME 2024
Neda Nikpoor, MD, talks about the Light Adjustable Lens at ASCRS 2024
Elizabeth Yeu, MD, highlights from a corneal case report for a patient undergoing the triple procedure
© 2024 MJH Life Sciences

All rights reserved.