Acute rises in IOP that occur with anti-VEGF injections is a real phenomenon, but it is transient and may not necessarily warrant any intervention for many patients, according to Matthew Schlenker MD, MSc.
Chronic IOP spikes
Chronic rises in IOP can occur as a result of numerous mechanisms, such as silicone microdroplets from syringes associated with anti-VEGF injections, protein aggregates of the anti-VEGF therapies themselves, particularly if they have been stored for some time, direct toxic effects on the trabecular meshwork, inflammation, and a decrease in nitrous oxide production.
“It is thought that there are certain people at risk for chronic IOP rises, such as people who already have ocular hypertension,” he said, noting such patients have their outflow facility impaired after anti-VEGF injections.
Matthew Schlenker, MD, MSc, FRCPC
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This article was adapted from Dr. Schlenker’s presentation at the 51st Sally Letson Symposium in Ottawa, Ontario, Canada. Dr. Schlenker has no financial disclosures related to this content.