Analyses of cancer incidence and cause specific mortality patterns for long-term hereditary retinoblastoma survivors shows gender-related differences.
Reviewed by Ruth Kleinerman, PhD
The 10-year survival rate for patients with hereditary retinoblastoma is excellent, but these patients are at increased risk for developing secondary cancers and have elevated mortality compared to age-matched individuals in the general population.
According to analyses of data for retinoblastoma patients in the United States, there are gender-related differences in both the incidence of the different types of second non-ocular malignancies and cause-specific mortality, according to Ruth Kleinerman, PhD, deputy branch chief, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
“Based on this information, evidence-based guidelines for long-term surveillance and follow-up of retinoblastoma survivors should take gender into account,” Dr. Kleinerman said. “International pooling of second cancer data for retinoblastoma survivors will increase the number of cases of second cancers and provide statistical power to further investigate gender disparity in risk with greater precision.”
Information on the incidence of second cancers in retinoblastoma survivors and rates of mortality related to the subsequent cancers is available from the National Cancer Institute Long-term Follow-up Study of Retinoblastoma Survivors. The study includes data on 1,129 patients with hereditary retinoblastoma diagnosed between 1914 through 2006, of whom approximately 50% were still alive in 2016.
Ruth Kleinerman, PhD
E: [email protected]
This article is adapted from a presentation given by Dr. Kleinerman at the 2018 Ocular Oncology/Pathology Subspecialty Day meeting. Dr. Kleinerman has no relevant financial interests to disclose.