Advanced Medical Optics Inc. (AMO) sold six over-the-counter eye-care products to Inyx Inc., which will assign all of the business and marketing rights to its wholly owned marketing subsidiary, Exaeris Inc.
Charleston, SC—The brimonidine 0.2%/ timolol 0.5% fixed combination (Combigan, Allergan) administered twice daily is as effective as the concurrent use of brimonidine and timolol and is significantly more effective than monotherapy with either brimonidine three times daily or timolol twice daily, according to E. Randy Craven, MD, who presented his results at the American Glaucoma Society meeting here. The fixed combination is also superior to brimonidine monotherapy in long-term safety and the development of fewer ocular allergies, Dr. Craven said.
Irvine, CA—Visiogen Inc.'s dual-optic accommodating IOL (Synchrony) has received CE Mark designation.
Aliso Viejo, CA—Since FDA approval in 2003, more than 50,000 crystalens accommodating IOLs (eyeonics) have been implanted worldwide. Of these, 17,000 implants were with the crystalens SE second-generation lens (introduced in 2005), the company said in a prepared statement.
Irvine, CA—ISTA Pharmaceuticals Inc. announced it has filed a New Drug Application (NDA) with the FDA for its investigational ophthalmic product (T-Pred) containing tobramycin and prednisolone acetate in a fixed combination. The company hopes the drug receives approval as a treatment for inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial ocular infections or a risk of bacterial infections exists.
Oakbrook Terrace, IL—The Joint Commission on Accreditation of Healthcare Organizations (JCAHO) issued 2007 National Patient Safety Goals for ambulatory care facilities and offices in which surgery is performed.
Irvine, CA—Senju Pharmaceuticals will transfer exclusive North American rights of two investigational drugs—iganidipine, a calcium-channel blocker, and a new formulation of latanoprost, a prostaglandin analogue—to ISTA Pharmaceuticals. Both investigational formulations may treat glaucoma or other ophthalmic applications.
Commonly used systemic antihistamines taken for seasonal allergies can cause ocular surface drying that in turn aggravates ocular allergy symptoms. Antihistamine drops specifically formulated for ocular allergies, in contrast, do not appear to decrease tear volume or tear flow or cause ocular surface damage, according to several investigators who have studied ocular drying. However, in a separate mouse study, topical ocular allergy medications themselves may have different effects on tear volume or tear flow.
San Francisco—Discontinuing the use of cyclosporine ophthalmic emulsion 0.05% (Restasis, Allergan), the only FDA-approved drug to treat dry eye, may result in recurrence of the signs and symptoms of keratoconjunctivitis sicca (KCS), and reinstitution of the drug is needed to reverse those signs and symptoms, John Sheppard, MD, reported at the annual meeting of the American Society of Cataract and Refractive Surgery.
Azelastine is formulated to have a very long half life and a very high affinity for the H1 receptor it affects.