Dozens of peer-reviewed papers report the efficacy of IPL as an effective drug-free approach to treating ocular rosacea-associated and non-rosacea-associated meibomian gland dysfunction (MGD) and DED. This effect is thought to occur via multi-level impacts on the inflammation factors that drive both the MGD and DED components of ocular surface disease.1
IPL has been shown to improve noninvasive tear breakup time more than 5 seconds over baseline, and 86% of patients report improved symptoms.2 With three or four IPL treatments, spaced 2-5 weeks apart, we observe statistically significant reductions in MMP-9 levels and improved tear osmolarity.3
Patients then repeat IPL 1 or 2 times per year, depending on the severity of the underlying disease comorbidities. Additionally, recent confocal microscopic evidence exists for microstructure improvements of meibomian glands as well as significant decreases in peri-glandular inflammatory cells with IPL therapy.4
Patients report high satisfaction and appreciate the aesthetic benefits, such as improved eyelid redness, conjunctival redness and facial flushing.
1. Liu R, Rong B, Tu P, et al. Analysis of Cytokine Level in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction. AJO. 2017 Nov;183: 81-90.
2. Craig JP, Chen YH, Turnbull PR. Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2015 Feb 12;56(3):1965-70.
3. unpublished data
4. Yin Y, Liu N, Gong L, Song N. Changes in the Meibomian Gland After Exposure to Intense Pulsed Light in Meibomian Gland Dysfunction (MGD) Patients. cure Eye Res. 2018 Mar;43(3): 308-313.
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