Elucidation of the mechanisms leading to the development of exfoliation syndrome hold the key to non-IOP-lowering interventions that might prevent or reverse disease.
Reviewed by Robert Ritch, MD
Elucidation of the pathophysiology and genetics of exfoliation syndrome (XFS) may lead to the development of targeted therapy for this protean disorder with the potential to prevent, reverse, or even cure about 20% of glaucoma globally, said Robert Ritch, MD.
“Exfoliation syndrome is a systemic disorder of extracellular matrices (ECMs) that was first described 100 years ago, but its importance was largely ignored for the first 90 of those years,” said Dr. Ritch, Shelley and Steven Einhorn Distinguished Chair at New York Eye and Ear Infirmary of Mount Sinai, New York, NY.
Glaucoma is an ocular manifestation of this systemic disease with distinct genetic, biomechanical, cellular, and pathophysiologic mechanisms leading to dysfunction of the trabecular meshwork, according to Dr. Ritch.
“By understanding these mechanisms, we could potentially identify non-IOP-lowering treatment modalities that are applicable at various steps of disease development,” he said.
Robert Ritch, MD
E: [email protected]
This article was adapted from Dr. Ritch’s presentation during Glaucoma Subspecialty Day at the 2018 meeting of the American Academy of Ophthalmology. Dr. Ritch did not indicate any proprietary interest in the subject matter.