An abundance of evidence demonstrates the efficacy of intracameral antibiotics for reducing the risk of postcataract surgery endophthalmitis. In the United States, however, there is no commercially available antibiotic approved for intracameral use. Dr. Trattler noted that with the use of compounded medications, there is a risk for sight-threatening toxic anterior segment syndrome.
In the interest of minimizing that risk, Dr. Trattler said he is obtaining antibiotics for intracameral administration from a 503B compounding pharmacy that are held to higher regulatory standards for quality control. He added, “Some surgeons in the US recommend using a consent form when using a compounded medication considering the risks and chance of a compounding error.”
William D. Trattler, MD
Dr. Trattler is a consultant to EyePoint, Omeros, Ocular Therapeutix, and other companies that provide medications used perioperatively for cataract and refractive lens surgery.