Results from the 36-month Hyperopia Treatment Study 1 (HTS1) comparing immediate versus delayed spectacle treatment for moderate hyperopia in children 1 to <3 years of age are consistent with showing a small to moderate benefit or no benefit of immediate glasses compared with careful observation and glasses if deterioration occurs.
The study randomized patients 1:1 to either observation with glasses not prescribed unless the child met deterioration criteria or immediate prescription of glasses to be worn for the study duration. Its primary outcome, analyzed at study conclusion, compared rates of failure at study conclusion, with failure defined as “doing harm” to visual acuity, stereoacuity, or alignment.
The results showed a 13% lower failure rate in the group randomized to immediate glasses compared with the observation group (21% vs. 34%), but the difference between groups was not statistically significant (P=.14).
The findings from the National Eye Institute-supported study conducted by the Pediatric Eye Disease Investigator Group were reported for the first time by Donny W. Suh, MD, at the Pediatric Subspecialty Day meeting.
Dr. Suh said, “Our estimates of failure after 3 years with follow-up every 6 months did not allow us to make any definitive recommendations about management for these children.”