Dr. Berdahl also presented research that showed that CSF starts to decrease at age 65, which is also the time when the glaucoma risk tends to increase.
If CSF pressure is something that glaucoma specialists should treat, they could potentially do so with devices or drops to help raise it, Dr. Berdahl said.
"You could use a target other than [glaucoma specialists] saying, 'You seem to be getting worse.' It would be nice to have objective reasons to say what is the translaminar gradient and how you'd approach it," he said.
Dr. Berdahl also shared an example from what he called an out-of-the-box idea where if the atmospheric pressure is 0, the IOP was 22, and the CSF was 9, there would be a differential of 13 mm across the optic nerve head.
"If you lower the pressure in the front of the eye, that can lower the pressure inside the eye," he said. "You could create a chamber and creative a negative pressure vacuum."
That would release some of the atmospheric pressure and dial in eye pressure inside the eye.
John Berdahl, MD
E: [email protected]
This article was adapted from Dr. Berdahl's presentation during Glaucoma Subspecialty Day at the 2017 meeting of the American Academy of Ophthalmology. Dr. Berdahl is founder and chief executive officer of Equinox.