Some doxycycline benefit
A single, controlled trial investigating doxycycline randomized 150 patients to doxycycline 20 or 200 mg twice daily or placebo. Its results showed the doxycycline groups had significantly improved TBUT and Schirmer test scores compared with the controls. Doxycycline treatment was not associated with improvement in visual acuity or corneal staining.
“The findings of these studies suggest there is some benefit to doxycycline, but it is certainly not the home run we would expect for a medicine we reach for,” Dr. Wladis said.
The literature review identified two articles reporting on minocycline. One was a randomized trial assigning 60 patients to treatment with artificial tears with or without minocycline and found the minocycline group benefited with improved TBUT, staining scores, and lid margin health.
“These results suggest some benefit for minocycline, but it was compared to an inferior modality,” Dr. Wladis said.
The second report was an observational study of 16 patients treated for meibomitis. After 3 months, there was improvement in eyelid appearance and health, but not in corneal staining or the Schirmer scores.