Take-home message: Microstent implantation had favorable and safe results in a group of patients with open-angle glaucoma in the DUETTE trial.
La Jolla, CA—A certain glaucoma micro-stent (CyPass Micro-Stent, Transcend Medical) appears safe for patients looking to reduce reliance on multiple glaucoma medications, and for lowering IOP, said Quang H. Nguyen, MD.
Microinvasive glaucoma surgery (MIGS) devices, such as this implant, are important for glaucoma patients and surgeons because of their ab interno approach, minimal damage to tissue, superior safety, and low complication profile compared with traditional surgery, said Dr. Nguyen, associate head, Division of Ophthalmology, and director, Glaucoma Service, Cataract and Anterior Segment, Scripps Health Clinic, La Jolla, CA.
About the DUETTE trial
Although various trials are under way for the device, Dr. Nguyen spoke about the DUETTE trial. The implant is an investigational device in the United States.
Other trials have included or are including the device, such as the COMPASS study in the United States, which, Dr. Nguyen said, is the largest MIGS trial to date. The COMPASS study includes 505 patients for 2 years of follow up. Results with the COMPASS trial have been statistically significantly positive across all endpoints at both 1 and 2 years, he noted.
The DUETTE trial included 65 open-angle glaucoma patients refractory to medications receiving the device as a stand-alone procedure. The trial took place at eight sites in four European countries. The mean outcomes were adverse events, mean IOP, and IOP lowering at 12 months.
Patients included in the trial had grade III or IV open-angle glaucoma and a medicated IOP between 21 and 35 mm Hg with the use of one to four glaucoma medications. Patients could be phakic or pseudophakic. At the time of enrollment, the included patients were under consideration for a trabeculectomy.