Uveitis is an inflammation of the uvea, which includes the iris, choroid and the ciliary body in the eye. If left untreated, it can lead to vision loss, including cataracts, glaucoma and cystoid macular oedema.
By some estimates, severe vision loss occurs in 25% to 30% of paediatric uveitis cases, making early diagnosis and treatment essential to preserve vision in children with the disease. Juvenile idiopathic arthritis is the most common systemic disorder associated with uveitis in children, accounting for more than 75% of cases of paediatric anterior uveitis.
Clinicians have long relied on corticosteroids to treat uveitis. These treatments frequently cause ocular and systemic adverse events, so immunosuppressant therapies, including methotrexate, have emerged as an alternative, or second-line therapy.
Adalimumab effectively lowers inflammation in multiple disorders.