3) Ranibizumab gets new FDA approved indications
Whenever a vascular endothelial growth factor (VEGF) inhibitor gets a new FDA-approved clinical indication, it makes my top 5. If an anti-VEGF gets two new indications in the same year, you definitely make my top 3 and that is where ranibizumab (Lucentis, Genentech) sits on my list.
In January of this year, ranibizumab became the first anti-VEGF therapy approved to treat patients with myopic choroidal neovascularization (mCNV) in the United States. To follow that up in April 2017, ranibizumab received FDA approval for the treatment of all forms of diabetic retinopathy.
While I believe aflibercept (Eylea, Regeneron) will also eventually achieve these FDA-approved indications in the near future, these approvals for ranibizumab are a great step forward for the entire class of anti-VEGF inhibitors.