The EAGLE Study
The 31-site, randomized EAGLE Study (Trials 2011; 12: 133. DOI: 10.1186/1745-6215-12-133) evaluated if patients with PAC or PACG benefited from early lens extraction by analyzing if the patient reports, clinical measures, or cost effectiveness improved.
The participating patients were 50 years or older with newly diagnosed PACG or PAC and IOPs over 30 mm Hg. The angle closure was 180 degrees or more and patients had a nonvisually relevant cataract. The patients were randomized to lens extraction or a LPI and followed for 3 years. The primary outcomes were the patient-centered health status determined by the EQ-5D questionnaire, the IOP at 3 years, and the incremental cost per quality-adjusted life year gained. The results are forthcoming.
Dr. Bhorade summarized, “Based on what is known thus far about cataract surgery and its appropriateness for patients with PAC and PACG…some studies have suggested that cataract surgery may be an appropriate treatment to lower IOP [in patients with a visually significant cataract]. In patients with a nonvisually significant cataract, cataract surgery may be appropriate after a patient has had an LPI and the IOP remains uncontrolled. However, the role of cataract surgery as an initial treatment for PAC/PACG in a patient with a nonvisually significant cataract remains unclear. Results from the EAGLE study may help clarify this answer.”
Editorial from Peter McDonnell, MD: Dopamine, my drug of choice