Detecting significant differences
Current endpoints often are not sensitive enough to detect clinically meaningful changes in patient visual function with some retinal diseases, especially in early stages of the disease.
One presentation described development of a portable visual navigation challenge, a maze through which subjects must navigate a marked path with a series of obstacles under homogenous, modifiable lighting conditions (Shapiro et al. ARVO E-Abstract 3290). This device was able to detect significant differences between three cohorts of subjects: those with normal vision, and those with simulated mild or severe retinitis pigmentosa (RP).
Having a portable and effective test that is able to detect differences in visual function due to RP could decrease the cost and time restraints that are often barriers to trials.