A novel topical high-concentrated, crosslinked hyaluronic acid eye drop could expand the options that surgeons have available for improving wound care, healing, and regenerative medicine for a variety of corneal injuries.
Patients treated with OBG (arm 1) had faster recovery time compared to both comparison and control groups (See Table 1). OBG alone demonstrated accelerated wound healing versus standard of care in roughly 55% more patients as measured as wounds closed on day 3.
Additionally, wound size was as much as ~36% smaller as early as day 1 (24 hours post-surgery) and 83% smaller by day 3 with OBG alone. The safety and tolerability were excellent with no safety concerns nor product related adverse events due to OBG.
The BCL subjects did have 1 patient each in arm 1 and arm 2 with recurrent epithelial defects occurring after the BCL was removed, requiring the BCL to be replaced.7
Clinical therapies are needed that can be easily applied topically to accelerate the repair of a variety of corneal and surface epithelial injuries. Based on the pilot study, this high-concentration, crosslinked HA eye drop demonstrated the ability to effectively and safely accelerate re-epithelialization of large corneal epithelial defects created during PRK.
BARBARA WIROSTKO, MD
E: [email protected]
Dr. Wirostko is chief medical officer for EyeGate Pharmaceuticals; co-founder of Jade Therapeutics; and adjunct professor of ophthalmology, Moran Eye Center, University of Utah, Salt Lake City. She is also a stockholder in EyeGate.
1. Wirostko B, Mann BK, Williams DL, Prestwich GD. Ophthalmic uses of a thiol-modified hyaluronan-based hydrogel. Adv Wound Care (New Rochelle) 2014; 3:708-716.
2. Yang G, Prestwich GD, Mann BK. Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Vet Sci 2011; Article ID 851593. doi: 10.5402/2011/851593. Accessed July 7, 2017 at http://dx.doi.org/10.5402/2011/851593
3. Williams DL, Mann BK. A crosslinked HA-based hydrogel ameliorates dry eye symptoms in dogs. Int J Biomater 2013, Article ID 460437. Accessed July 7, 2017 at http://dx.doi.org/10.1155/2013/460437
4. Yang G, Espandar L, Mamalis N, Prestwich GD. A crosslinked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits. Vet Ophthalmol 2010; 13:144-150.
5. Williams DL, Wirostko BM, Gum G, Mann B. Topical crosslinked HA-based hydrogel accelerates closure of corneal epithelial defects and repair of stromal ulceration in companion animals. Invest Ophthalmol Vis Sci. 2017;58:4616-4622. doi: 10.1167/iovs.16-20848.
6. Williams DL, Mann BK. Efficacy of a crosslinked hyaluronic acid-based hydrogel as a tear film supplement: a masked controlled study. PLoS ONE 2014; 9: e99766. doi:10.1371/journal.pone.0099766. Accessed July 7, 2017 at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099766
7. Daniel S. Durrie MD, Darcy Wolsey, MD, MPH, Vance Thompson, MD, Carol Assang, Brenda Mann, PhD, Barbara Wirostko, MD. Accelerating re-epithelialization after photorefractive keratectomy with an ocular bandage gel. Journal of Cataract and Refractive Surgery. Accepted and in press Nov 2017.