Editor’s Note: Welcome to “Eye Catching: Let's Chat,” a blog series featuring contributions from members of the ophthalmic community. These blogs are an opportunity for ophthalmic bloggers to engage with readers with about a topic that is top of mind, whether it is practice management, experiences with patients, the industry, medicine in general, or healthcare reform. The views expressed in these blogs are those of their respective contributors and do not represent the views of Ophthalmology Times or UBM Medica. This is part three of a three-part Clinical Innovations series discussing the results from case studies using an at-home monitoring system for patients with AMD. Joshua Mali, MD, is a vitreoretinal surgeon at The Eye Associates, a private multispecialty ophthalmology practice in Sarasota, FL.
As of 2014, more than 15 million Americans are estimated to have age-related macular degeneration (AMD).i The percentage of patients who will progress from early or intermediate dry AMD to advanced stages of the disease over five years ranges from 0.5% to 45%, depending on a number of risk factors including drusen size and retinal pigment epithelium (RPE) changes.ii On average, however, studies have shown that the median progression rate of dry AMD ranges from 1.49 mm2 per year to 2.29 mm2 per year. iii
However, the ability to predict which patients will have a rapid rate of progression and which will be unlikely to progress significantly over time is highly challenging, if not impossible. In addition to the AREDS 5-year risk scale,2 other risk factors, such as family history and lifestyle, may make progression more likely although there is no definitive progression model.
This uncertainty understandably causes great anxiety for patients and doctors alike as we work diligently to detect the progression from dry AMD to wet AMD as soon as possible. With the home-use monitoring device (ForeseeHome device, Notal Vision), we finally have a viable option for consistent, accurate monitoring and early detection.
Impact to treatment plan
The device allows me to catch wet AMD early in the conversion process. Prior to utilizing it, I did not have many options for monitoring my patients with AMD. My patients were generally put on the AREDS2 vitamin formulation recommended in the Age-Related Eye Disease Study 2 (AREDS2) and instructed not to smoke, have a good diet, exercise regularly, and utilize sunglasses.
In addition, they were also given an Amsler grid to self-monitor for any vision changes. However, predicting which patients will truly progress to wet AMD, and when, is a challenge. While the Amsler grid has helped many patients since its development, its ability to detect change is inconsistent.iv
Additionally, by the time the patient notices a significant difference in his or her own visual acuity, severe and potentially irreversible damage might have already transpired. With the home-use device, patients and doctors do not need to rely solely on utilizing a lined piece of paper to prompt recognition of visual acuity changes.
Now, we have a more objective, reliable tool that can detect minute changes and directly alert the eye-care provider when there are significant changes in vision and retinal anatomy. Once an alert is issued, we can schedule an immediate follow-up appointment and perform an examination to confirm choroidal neovascularization (CNV).
Fortunately, of the more than 100 patients I currently have on the device, I have had only a few patients receive non-CNV alerts and only two patients who have had a CNV alert.
My first case involves a 75-year-old female with a history of exudative AMD in her left eye – treated with intravitreal aflibercept (Eylea, Regeneron) and intermediate dry AMD in her right eye. Her visual acuity was 20/30 OD at baseline. When the device alert was triggered, the patient was asymptomatic yet I still instructed her to come to the office as soon as possible for an evaluation.
Upon examination of the patient (Figure 1), she was still 20/30 OD and the OCT (Figure 2) had borderline findings, however, a small CNV membrane was confirmed on fluorescein angiography (Figure 3). Of note, the location of the CNV was just temporal to the optic disc and therefore not involving the central macula at this point.
Consequently, the patient was asymptomatic and the conversion to exudative AMD was confirmed solely with clinical examination and additional testing with OCT and fluorescein angiography. The aflibercept treatment was initiated and the patient is currently 20/25 OD.
The home-use device was critical in bringing this patient into my office for evaluation and allowed for prompt management. As this patient was already receiving treatment for wet AMD in her fellow eye, she knew the stakes were high and was happy for the early detection and saving her sight.
Dr. Mali’s relevant financial disclosures include the following: Notal Vision Inc. (consultant, speaker), Regeneron (consultant, speaker, stock shareholder, research funding).
i Wong WL, Su X1, Li X, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2(2):e106-116.
iiDavis MD, Gangnon RE, Lee LY, et al. Age-Related Eye Disease Study Group. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol. 2005;123:1484-1498.
iiiLim PC, Layton CJ. Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design. Clin Exp Ophthalmol. 2016;44:410-421.
ivCrossland M, Rubin G. The Amsler chart: absence of evidence is not evidence of absence. Br J Ophthalmol. 2007;91:391-393.