A novel topical high-concentrated, crosslinked hyaluronic acid eye drop could expand the options that surgeons have available for improving wound care, healing, and regenerative medicine for a variety of corneal injuries.
Hyaluronic acid (HA) hydrogels have long been recognized for their dermal and ocular wound-healing properties, ability to support stem-cell regenerative medicines, joint lubrication and cushioning, and ocular hydrating capabilities.1
In Europe and Asia, topical HA is the standard of care for dry eye, as well as other corneal superficial epithelial injuries. Topically applied, non-crosslinked HA eye drops are quickly degraded and cleared.
However, HA can be customized for composition, physical form, and biomechanical properties by crosslinking its chemical structure, resulting in a high-concentrated substance that resists degradation. It also has the ability to stay longer on both dermal and ocular epithelial surfaces than non-crosslinked versions.1,2
BARBARA WIROSTKO, MD
E: [email protected]
Dr. Wirostko is chief medical officer for EyeGate Pharmaceuticals; co-founder of Jade Therapeutics; and adjunct professor of ophthalmology, Moran Eye Center, University of Utah, Salt Lake City. She is also a stockholder in EyeGate.
1. Wirostko B, Mann BK, Williams DL, Prestwich GD. Ophthalmic uses of a thiol-modified hyaluronan-based hydrogel. Adv Wound Care (New Rochelle) 2014; 3:708-716.
2. Yang G, Prestwich GD, Mann BK. Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Vet Sci 2011; Article ID 851593. doi: 10.5402/2011/851593. Accessed July 7, 2017 at http://dx.doi.org/10.5402/2011/851593
3. Williams DL, Mann BK. A crosslinked HA-based hydrogel ameliorates dry eye symptoms in dogs. Int J Biomater 2013, Article ID 460437. Accessed July 7, 2017 at http://dx.doi.org/10.1155/2013/460437
4. Yang G, Espandar L, Mamalis N, Prestwich GD. A crosslinked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits. Vet Ophthalmol 2010; 13:144-150.
5. Williams DL, Wirostko BM, Gum G, Mann B. Topical crosslinked HA-based hydrogel accelerates closure of corneal epithelial defects and repair of stromal ulceration in companion animals. Invest Ophthalmol Vis Sci. 2017;58:4616-4622. doi: 10.1167/iovs.16-20848.
6. Williams DL, Mann BK. Efficacy of a crosslinked hyaluronic acid-based hydrogel as a tear film supplement: a masked controlled study. PLoS ONE 2014; 9: e99766. doi:10.1371/journal.pone.0099766. Accessed July 7, 2017 at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099766
7. Daniel S. Durrie MD, Darcy Wolsey, MD, MPH, Vance Thompson, MD, Carol Assang, Brenda Mann, PhD, Barbara Wirostko, MD. Accelerating re-epithelialization after photorefractive keratectomy with an ocular bandage gel. Journal of Cataract and Refractive Surgery. Accepted and in press Nov 2017.